Features | Partner Sites | Information | LinkXpress
Sign In
Advantech Europe

Implant Stiffness Leads to Foreign Body Reactions

By HospiMedica International staff writers
Posted on 25 Feb 2014
Image: Cell Morpholgy in relation to surface stiffness (Photo courtesy of the University of Cambridge).
Image: Cell Morpholgy in relation to surface stiffness (Photo courtesy of the University of Cambridge).
A new study reveals that surgical implant stiffness is a major cause of foreign body reaction (FBR) inflammatory reactions.

Researchers at the University of Cambridge (United Kingdom) implanted composite foreign bodies—one side as soft as neural tissue and the other as stiff as muscle—into rats' brains to examine the impact of an implant's stiffness on the inflammatory process. The researchers found that both primary rat microglial cells and astrocytes responded to the increased contact stiffness by changes in morphology and upregulation of a multitude of inflammatory genes and proteins, with FBR significantly enhanced around the stiff portions of the implant.

The researchers found that the morphologically, the cells around the stiffer substrate were very flat, whereas those grown on the softer substrate looked much more like normal cells found in the brain. According to the researchers, the results suggest that adapting the surface stiffness of electrodes used as neural implants for the stimulation of nervous tissue could minimize adverse reactions and improve biocompatibility. The study was published early online on February 11, 2014, in Biomaterials.

“Brain tissue is as soft as cream cheese; it is one of the softest tissues in the body, and electrodes are orders of magnitude stiffer. The findings could have major implications for the design of implants used in the brain and other parts of the body,” said study coauthor Kristian Franze. “Our results suggest that in the short term, simply coating existing implants with materials that match the stiffness of the tissue they are being implanted into will help reduce foreign body reactions.”

Implant FBR in the brain can cause the implants to be encapsulated by reactive tissue, which in the CNS consists mainly of microglial cells and astrocytes, which are surrounded by extracellular matrix (ECM). The reactive process, which starts with the activation of glial cells, can damage local neurons, and the subsequent dendritic retraction and neuronal death may contribute to a gradual decline in the function of implanted electrodes.

Related Links:

University of Cambridge 

Asian Healthcare Show
Cincinnati Sub-Zero


Critical Care

view channel
Image: Myoglobin (red) includes a pocket that is used to store heme (green) (Photo courtesy of Jeff Fitlow/Rice University).

Whales Could Hold the Answer for Synthetic Blood

Ultra-stable proteins that allow deep-diving whales to remain active while holding their breath could help create lifesaving synthetic blood, claims a new study. Researchers at Rice University (Rice,... Read more

Women's Health

view channel

Pregnancy Complications Raise Heart Disease Risk

A new study suggests a high correlation between women who experienced complications during pregnancy and those facing death from heart disease later in life. Researchers at the Public Health Institute (PHI; Oakland, CA, USA; Berkeley, CA) conducted a study involving 14,062 women, examining pregnancy events over five... Read more

Patient Care

view channel
Image: The NIFTY cup (Photo courtesy of PATH).

NIFTY Cup Aids Infants Who Cannot Breastfeed

A novel cup has been designed to facilitate feeding and prevent starvation in infants in developing countries who are unable to breastfeed. The Neonatal Intuitive Feeding TechnologY (NIFTY) cup, developed... Read more

Hospital News

view channel

Roche Opens Diagnostics Training Center in Liverpool Hospital

Roche (Basel, Switzerland) has opened a new diagnostics training laboratory and regional center of excellence at the Royal Liverpool University Hospital (RLUH; United Kingdom). The facility, which is part of Liverpool Clinical Laboratories (United Kingdom), will provide training for more than 1,000 hospital and laboratory... Read more


view channel

Medical and Imaging Technologies Transform Healthcare Sector

An array of sophisticated inventions in medical devices, diagnostics, and imaging from diverse industries will remain at the heart of medical diagnosis and treatment, with the potential to address needs across developed, developing, and emerging countries. The Frost & Sullivan (Frost; London, United Kingdom) Top... Read more
Copyright © 2000-2015 Globetech Media. All rights reserved.