Features | Partner Sites | Information | LinkXpress
Sign In
Advantech Europe

Gold Nanoparticles Prevent Infection on Orthopedic Implants

By HospiMedica International staff writers
Posted on 23 Jul 2014
Gold (Au) nanoparticles help prevent the formation of antibiotic resistant biofilm on the surface of orthopedic implants, according to a new study.

Researchers at the Shanghai Institute of Ceramics (CIS; China) extrapolated that since gold nanoparticles can pass electrons to titanium dioxide (TiO2), they could be used to induce bacterial death. Due to a phenomenon known as localized surface plasmon resonance (a collective oscillations of electrons), an Au@TiO2 system could effectively kill bacteria in darkness by affecting respiratory electrons of the bacterial membrane, making them steadily lose electrons by transferring them first to the Au nanoparticles and then to TiO2, until they die.

To do so, they prepared close-packed TiO2 nanotube arrays on a metallic Ti surface by electro-chemical anodization. Then, using magnetron sputtering, they deposited Au nanoparticles to coat the Ti surfaces. The researchers then allowed Staphylococcus aureus and Escherichia coli to grow separately on the arrays. They found that both organisms were highly unsuccessful, exhibiting profuse membrane damage and cell leakage. The study describing the technology was published on June 30, 2014, in the journal Applied Physics Letters.

“Implant-associated infections have become a stubborn issue that often causes surgery failure. Designing implants that can kill bacteria while supporting bone growth is an efficient way to enhance in vivo osteointegration,” concluded senior author Prof. Xuanyong Liu, PhD. “This work provides insights for the better understanding and designing of noble metal nanoparticles-based plasmonic heterostructures for antibacterial application.”

TiO2 is able to kill bacteria itself due to its properties as a photocatalyst; when the metal is exposed to light, it becomes energetically excited by absorbing photons. This generates electron-hole pairs, turning Ti into a potent electron acceptor that can destabilize cellular membrane processes by usurping their electron transport chain's terminal acceptor. The dark conditions inside the human body, however, limit the bacteria-killing efficacy of TiO2. Gold nanoparticles, though, can continue to act as antibacterial terminal electron acceptors under darkness, due to localized surface plasmon resonance at the interface between conductors and dielectrics, such as between gold and TiO2.

Related Links:

Shanghai Institute of Ceramics

Cincinnati Sub-Zero
Asian Healthcare Show


Women's Health

view channel

Pregnancy Complications Raise Heart Disease Risk

A new study suggests a high correlation between women who experienced complications during pregnancy and those facing death from heart disease later in life. Researchers at the Public Health Institute (PHI; Oakland, CA, USA; Berkeley, CA) conducted a study involving 14,062 women, examining pregnancy events over five... Read more

Patient Care

view channel
Image: The NIFTY cup (Photo courtesy of PATH).

NIFTY Cup Aids Infants Who Cannot Breastfeed

A novel cup has been designed to facilitate feeding and prevent starvation in infants in developing countries who are unable to breastfeed. The Neonatal Intuitive Feeding TechnologY (NIFTY) cup, developed... Read more

Hospital News

view channel

Universal Health Services to Acquire Foundations Recovery Network

Hospital operator Universal Health Services (UHS; King of Prussia, PA, USA) has entered an agreement to buy addiction treatment provider Foundations Recovery Network (FRN; Brentwood, TN, USA) for USD 350 million. Founded in 1995, FRN is a leader in addiction treatment and focused on treating adults with addiction and... Read more


view channel

GE Healthcare to Support Emerging Market Health

GE Healthcare (GE; Little Chalfont, United Kingdom) has announced the creation of a new business unit that will develop solutions to improve emerging market health outcomes. The new Sustainable Healthcare Solutions (SHS) business will focus on the expansion of the company’s affordable healthcare portfolio, including... Read more


08 Oct 2015 - 10 Oct 2015
08 Oct 2015 - 10 Oct 2015
08 Oct 2015 - 10 Oct 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.