Features | Partner Sites | Information | LinkXpress
Sign In
KOREA E & EX
Advantech Europe
Schiller

HPV Vaccine Leads to Big Drop in Papilloma Prevalence

By HospiMedica International staff writers
Posted on 03 Jul 2013
The prevalence of human papillomavirus (HPV) infection in young women has declined by more than half since the introduction of the HPV vaccine, despite low vaccine uptake, claims a new study.

Researchers at the US Centers for Disease Control and Prevention (CDC; Atlanta, GA, USA) conducted a study that analyzed HPV prevalence data from the prevaccine (2003–2006), and the vaccine era (2007–2010), collected from US national health and nutrition examination surveys. HPV prevalence was determined by the linear array assay in cervicovaginal swab samples from females aged 14–59 years; 4,150 women provided samples in 2003–2006, and 4,253 provided samples in 2007–2010.

The results showed that among females aged 14–19 years, the vaccine-type HPV prevalence (HPV-6, -11, -16, or -18) decreased from 11.5% in 2003–2006 to 5.1% in 2007–2010, a decline of 56%. Among other age groups, the prevalence did not differ significantly between the two periods. The researchers stressed that the decline in HPV infection rate occurred despite the fact that only a third of eligible patients received the vaccine, and that vaccine effectiveness of at least one dose was 82%. The study was published in the June 19, 2013, issue of the Journal of Infectious Disease.

“Our data suggest an early impact of HPV vaccination on vaccine type prevalence among females in the United States and high vaccine effectiveness against vaccine type infection,” concluded lead author Lauri Markowitz, MD, and colleagues of the CDC. “The decline in vaccine type prevalence is higher than expected and could be due to herd immunity from vaccination, vaccine effectiveness of a series involving less than three doses, and/or changes in sexual behavior that we did not measure.”

“The results should challenge healthcare professionals to redouble their efforts to improve HPV vaccination rates, which lag far behind many undeveloped nations,” said Anne Schuchat, MD, director of the CDC's National Center for Immunization and Respiratory Diseases. “Here we're finding out about a vaccine that has greater than expected performance even with our pathetic coverage, and I think that this audience of highly motivated immunization experts and clinicians and program staff, I hope, see this as a wake-up call for us to do much better.”

Introduced in 2006, the first HPV vaccine covered the four viral strains most closely associated with gynecologic cancer (HPV-6, 11, 16, and 18). In June 2012, the CDC advisory committee on immunization practices (ACIP) recommended routine vaccination of 11- and 12-year-old girls with three doses of the quadrivalent vaccine, and catch-up vaccination of girls and young women 13 through 26. In 2009, the ACIP updated the recommendation to include the bivalent vaccine (HPV-16 and 18); two years later, ACIP recommended routine vaccination of boys and young men.

Related Links:
US Centers for Disease Control and Prevention



Channels

Critical Care

view channel
Image: Global malaria death rates (Photo courtesy of the WHO Global Malaria Program).

Imminent Danger of Drug-Resistant Malaria Spreading from Myanmar

Resistance of the malaria parasite P. falciparum to artemisinin has been spreading and is on the verge of entering India, according to a new study. Researchers at Mahidol University (Bangkok, Thailand),... Read more

Surgical Techniques

view channel

Duodenal Switch Imperative for Bariatric Surgery Success

The duodenal switch component of biliopancreatic diversion with duodenal switch (BPD/DS) is the key to persistent reductions in body weight and body fat, according to a new study. Researchers at the Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ; Canada) conducted a murine study to examine the... Read more

Health IT

view channel
Image: Remote Intelligent Telehealth Assistant (RITA) (Photo courtesy of PR Newswire).

Telehealth Robot Launched to Increase Productivity of Doctors in Clinics and Hospitals

A robot uses high-definition monitors, high-speed components, and wireless communications, and serves as a telehealth media center to give doctors more flexibility in treating and assisting patients remotely.... Read more

Hospital News

view channel

Patient Navigators Help Reduce Emergency Department Visits

Employing patient navigators—nonclinical staff members who connect patients with essential care services—can significantly reduce the overuse of emergency departments (EDs) and the number of hospital readmissions. A pilot program conducted at three hospitals in western Pennsylvania (USA), St. Vincent Health System (Erie,... Read more

Business

view channel

Pfizer to Buy Hospira to Bolster Hospital Products

Pfizer (New York, NY, USA) has entered into a definitive merger agreement with Hospira (Lake Forest, IL, USA), in a move designed to significantly enhance their global established pharmaceutical (GEP) business, for a total enterprise value of approximately USD 17 billion. The strategic complementary combination will... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.