Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Advantech Europe
VIEWORKS

High Blood Pressure May Be More Dangerous for Women

By HospiMedica International staff writers
Posted on 13 Jan 2014
A new study has identified significant differences in the mechanisms that cause high blood pressure in women, as compared to men.

Researchers at Wake Forest Baptist Medical Center (Winston-Salem, NC, USA) conducted a study involving 100 men and women age 53 and older (39% women) with untreated high blood pressure and no other major diseases. The researchers then utilized noninvasive impedance cardiography, applanation tonometry, and plasma measures of angiotensin II, angiotensin (1–7), serum aldosterone, high-sensitivity C-reactive protein (hs-CRP), and cytokine biomarkers of inflammation to characterize the hemodynamic and hormonal profile of the patients.

The results showed that despite there being no differences between women and men in terms of office blood pressure, heart rate, and body mass index (BMI), men demonstrated lower values of pulse pressure, systemic vascular resistance, brachial artery pulse wave velocity and augmentation index. In all, women had 30%–40% more vascular disease than men for the same level of elevated blood pressure. In addition, there were significant physiologic and hormonal differences in the women's cardiovascular system that contributed to the severity and frequency of heart disease.

In each of the hypertension categories, the increased blood pressure in men was associated with significant augmentations in stroke volume and cardiac output compared with women. Sex-related hemodynamic differences were associated in women with higher plasma levels of leptin, hs-CRP, plasma angiotensin II and serum aldosterone, and no differences in the serum concentrations of cytokinins. The study was published in the December 2013 issue of Therapeutic Advances in Cardiovascular Disease.

“The medical community thought that high blood pressure was the same for both sexes and treatment was based on that premise,” said lead author professor Carlos Ferrario, MD. “This is the first study to consider sex as an element in the selection of antihypertensive agents or base the choice of a specific drug on the various factors accounting for the elevation in blood pressure.”

“Our study findings suggest a need to better understand the female sex-specific underpinnings of the hypertensive processes to tailor optimal treatments for this vulnerable population,” added Dr. Ferrario. “We need to evaluate new protocols–what drugs, in what combination, and in what dosage—to treat women with high blood pressure.”

Related Links:

Wake Forest Baptist Medical Center



Channels

Critical Care

view channel
Image: The miniature Proxima Sensor and dedicated bedside monitor (Photo courtesy of Sphere Medical).

In-Line Analyzer Monitors Blood Gases Bedside

A novel miniaturized blood gas analyzer delivers true point-of-care testing (POCT), enabling fast response and proactive critical care. The Proxima system includes the miniature Proxima Sensor and... Read more

Surgical Techniques

view channel

Restricting Transfusions After Cardiac Surgery Shows No Benefit

A new study concludes that there is no health advantage if doctors wait until a heart surgery patient becomes substantially anemic before receiving a transfusion. Researchers at the University of Leicester (United Kingdom), Bristol Royal Infirmary (BRI; United Kingdom), and other institutions conducted a multicenter,... Read more

Health IT

view channel
Image: ResolutionMD across multiple devices (Photo courtesy of Calgary Scientific).

Healthcare Communication Platform Offers Seamless Image Access

Novel diagnostic medical imaging software offers better access to health information, supports increased teamwork, and enhances communication among practitioners and patients. ResolutionMD enables doctors... Read more

Business

view channel
Image: An Air Evac Lifeteam Bell 206 Long Ranger helicopter (Photo courtesy Air Evac Lifeteam).

KKR Seals Deal to Buy Air Medical Group for USD 2 Billion

KKR (New York, NY, USA) have agreed to acquire Air Medical Group Holdings (AMGH; Lewisville, TX, USA), a leading provider of air ambulance services, in a deal valued at USD two billion, including debt.... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.