We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Localized Cardiac Cooling May Limit Infarct Damage

By HospiMedica International staff writers
Posted on 22 Jan 2018
Print article
Image: A thermal image of a localized cooled heart (dark spot) (Photo courtesy of Catharina Hospital).
Image: A thermal image of a localized cooled heart (dark spot) (Photo courtesy of Catharina Hospital).
A new study suggests that cooling sections of the heart during a heart attack, both prior to and following an angioplasty, could limit cardiac damage.

Researchers at Eindhoven University of Technology (TUE; The Netherlands), Catharina Hospital (Eindhoven, The Netherlands), and other institutions conducted a study in 10 patients suffering acute myocardial infarction (MI), whose primary percutaneous coronary intervention (PPCI) included selective sensor-monitored intracoronary hypothermia based on saline at room temperature administered distal to the culprit lesion through an inflated over-the-wire-balloon (OTWB), in order to cool the endangered myocardium for 10 minutes.

Once the OTWB was deflated, cooling continued with saline at 4°C for another 10 minutes during the reperfusion phase. A sensor-tipped temperature wire in the distal coronary artery allowed titration of the infusion rate to achieve a desired coronary temperature of 6°C below body temperature, which was achieved within 27 seconds; routine PPCI was then performed. The results showed that in anterior wall MI, the protocol appeared safe, without serious hemodynamic or systemic side effects. In inferior wall MI, transient conduction abnormalities of short duration occurred. The study was published on December 8, 2017, in EuroIntervention.

“You can compare it with cooling the knee following a sports collision, for example, where an inflamed reaction occurs and the knee swells. To avoid this swelling, therefore, the muscles are often immediately cooled. We now apply the same principle to the heart muscle,” said lead author Luuk Otterspoor, MD, of TUE. “By cooling the part of the heart that is affected by a clogged or constricted coronary artery, there is less damage to the heart muscle after the constriction is opened up. We believe this can ultimately reduce the impact of the heart attack and damage to the heart by some 20-30 percent.”

During a PPCI angioplasty procedure, the constricted coronary artery should be opened up as quickly as possible. However, once blood begins to flow again, additional irreversible damage to the heart muscle is caused. This consequential damage, known as reperfusion injury, is the result of heart muscle cells swelling, which causes the capillaries to close. Animal models have shown that hypothermia reduces both reperfusion injury and infarct size, if started before PPCI reperfusion.

Related Links:
Eindhoven University of Technology
Catharina Hospital
Gold Member
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Medical Gas Blender
BlenderBuddy 1

Print article

Channels

Surgical Techniques

view channel
Image: NTT and Olympus have begun the world\'s first joint demonstration experiment of a cloud endoscopy system (Photo courtesy of Olympus)

Cloud Endoscopy System Enables Real-Time Image Processing on the Cloud

Endoscopes, which are flexible tubes inserted into the body's natural openings for internal examination and biopsy collection, are becoming increasingly vital in medical diagnostics. Their minimal invasiveness... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The PATHFAST hs-cTnI-II high-sensitivity troponin assay has been developed for the PATHFAST Biomarker Analyzer (Photo courtesy of Polymedco)

POC Myocardial Infarction Test Delivers Results in 17 Minutes

Chest pain is the second leading cause of emergency department (ED) visits by adults in the United States, generating over 7 million visits annually. In the event of a suspected heart attack, physicians... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.