We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App





Unique COVID-19 Vaccine Uses Modified Bovine Adenovirus to Provide Significantly Higher Levels of Immunity (B)

By HospiMedica International staff writers
Posted on 15 Oct 2020
Print article
Image: Unique COVID-19 Vaccine Uses Modified Bovine Adenovirus to Provide Significantly Higher Levels of Immunity (B) (Photo courtesy of CDC)
Image: Unique COVID-19 Vaccine Uses Modified Bovine Adenovirus to Provide Significantly Higher Levels of Immunity (B) (Photo courtesy of CDC)
A team of scientists are working to develop a unique COVID-19 vaccine that uses a bovine adenovirus as a safe and effective delivery vehicle with the aim of protecting all segments of the population, especially older adults.

Adenoviruses have emerged as a promising gene-delivery platform for therapeutic and vaccine purposes. However, human adenoviruses are widespread and can cause common illnesses such as cold-like symptoms, fever, sore throat, bronchitis, pneumonia, diarrhea and pink eye. As a result, most people may have preexisting immunity that could impact the efficacy of vaccines delivered via a human-adenovirus-based vector.

Scientists at the Pennsylvania State University (University Park, PA, USA) have adapted an adenovirus typically found in cattle to prevent it from replicating, which enhances safety. The researchers have also modified the adenovirus to express a peptide that stimulates a robust immune response to influenza viruses in mice. According to the researchers, because SARS-CoV-2 is a newly emerged virus for which humans have no previous immunity, any vaccine will have to be highly immunogenic to provide protection, particularly among older adults, whose immune systems naturally decline with age.

"Our preliminary work has revealed that this novel vaccine platform provides significantly higher levels of immunity compared to that of human adenovirus vectors," Kuchipudi said. "We hypothesize that immunization with this vector expressing relevant antigens of SARS-CoV-2 will strengthen an effective anti-COVID-19 immunity," said Suresh Kuchipudi, clinical professor of veterinary and biomedical sciences and associate director of Penn State's Animal Diagnostic Laboratory.

"This work suggests that the bovine adenovirus vector system could serve as an excellent delivery vehicle for the development of recombinant vaccines against emerging pathogens — for the elderly and other segments of the population," added Kuchipudi. "We believe this effort will yield an effective COVID-19 vaccine and could make a significant contribution to flattening the pandemic's trajectory and helping to manage its second wave."

Related Links:
Pennsylvania State University

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Forceps
BiClamp LAP

Print article

Channels

Critical Care

view channel
Image: The permeable wearable electronics developed for long-term biosignal monitoring (Photo courtesy of CityUHK)

Super Permeable Wearable Electronics Enable Long-Term Biosignal Monitoring

Wearable electronics have become integral to enhancing health and fitness by offering continuous tracking of physiological signals over extended periods. This monitoring is crucial for understanding an... Read more

Surgical Techniques

view channel
Image: NTT and Olympus have begun the world\'s first joint demonstration experiment of a cloud endoscopy system (Photo courtesy of Olympus)

Cloud Endoscopy System Enables Real-Time Image Processing on the Cloud

Endoscopes, which are flexible tubes inserted into the body's natural openings for internal examination and biopsy collection, are becoming increasingly vital in medical diagnostics. Their minimal invasiveness... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The PATHFAST hs-cTnI-II high-sensitivity troponin assay has been developed for the PATHFAST Biomarker Analyzer (Photo courtesy of Polymedco)

POC Myocardial Infarction Test Delivers Results in 17 Minutes

Chest pain is the second leading cause of emergency department (ED) visits by adults in the United States, generating over 7 million visits annually. In the event of a suspected heart attack, physicians... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.