We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App





Primate Study Reveals SARS-CoV-2 Immunosuppressive Effects for Development of COVID-19 Treatments and Vaccines

By HospiMedica International staff writers
Posted on 17 Nov 2020
Print article
Illustration
Illustration
Scientists have used a nonhuman primate model to identify features of the SARS-CoV-2 virus causing COVID-19 that could be useful for developing vaccines and treatment strategies.

The nonhuman primate model of COVID-19 infection was developed by the Korea Research Institute of Bioscience and Biotechnology (KRIBB Daejeon, Korea) and is the fourth model reported worldwide, following China, the Netherlands, and the US. The results of the study were part of a larger research project aimed at identifying key features of SARS-CoV-2 and testing for the efficacies of COVID-19 vaccines and treatments using the primate model.

In the primate study, the researchers investigated vascular abnormalities due to the infection, reasons underlying fatality of COVID-19 infection, particularly in immunocompromised patients, sites of SARS-CoV-2 multiplication inside human body, and the time-course. The research team showed, for the first time, that SARS-CoV-2 caused vascular inflammation and that the endotheliitis persisted even three days after the infection. Further, they confirmed immunosuppression, which is typically observed in patients with immunodeficiency, when the viral load increased precipitously during COVID-19 infection (first two days after getting infected).

The research team observed that the virus multiplied rapidly in the upper and lower respiratory tracts of the experimental primates in first two days after the viral infection. Subsequently, the viral load decreased quickly, and the viral activity was not detected seven days after the infection. These findings are expected to provide novel insights regarding the diagnostic challenges associated with a false positive test, i.e., a positive result of the reverse transcriptase polymerase chain reaction (RT-PCR) test for an asymptomatic person.

Related Links:
Korea Research Institute of Bioscience and Biotechnology (KRIBB)

Gold Member
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Gold Member
12-Channel ECG
CM1200B
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Transvaginal Tube
LiNA McCartney Tube

Print article

Channels

Critical Care

view channel
Image: The permeable wearable electronics developed for long-term biosignal monitoring (Photo courtesy of CityUHK)

Super Permeable Wearable Electronics Enable Long-Term Biosignal Monitoring

Wearable electronics have become integral to enhancing health and fitness by offering continuous tracking of physiological signals over extended periods. This monitoring is crucial for understanding an... Read more

Surgical Techniques

view channel
Image: NTT and Olympus have begun the world\'s first joint demonstration experiment of a cloud endoscopy system (Photo courtesy of Olympus)

Cloud Endoscopy System Enables Real-Time Image Processing on the Cloud

Endoscopes, which are flexible tubes inserted into the body's natural openings for internal examination and biopsy collection, are becoming increasingly vital in medical diagnostics. Their minimal invasiveness... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The PATHFAST hs-cTnI-II high-sensitivity troponin assay has been developed for the PATHFAST Biomarker Analyzer (Photo courtesy of Polymedco)

POC Myocardial Infarction Test Delivers Results in 17 Minutes

Chest pain is the second leading cause of emergency department (ED) visits by adults in the United States, generating over 7 million visits annually. In the event of a suspected heart attack, physicians... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.