We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Thermo Fisher Scientific - Direct Effect Media

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Left Breast RT Raises Coronary Artery Disease Risk

By HospiMedica International staff writers
Posted on 06 Oct 2021
Print article
Image: RT to the left breast raises cardiovascular risk (Photo courtesy of Shutterstock)
Image: RT to the left breast raises cardiovascular risk (Photo courtesy of Shutterstock)
Women with left-sided breast cancer (BC) undergoing radiation therapy (RT) have double the risk of subsequent heart disease, compared to those with right-sided BC, according to a new study.

Researchers at the University of Toronto (Canada), Memorial Sloan-Kettering Cancer Center (MSKCC; New York, NY, USA), and other institutions conducted a study in 972 women younger than 55 years of age who were diagnosed with BC between 1985 and 2008, and who also completed a cardiovascular health questionnaire. Risk of radiation-associated coronary artery disease (CAD) was then evaluated by comparing women treated with left-sided RT and women treated with right-sided RT.

The results, after a median follow-up time of 14 years, showed that 27.5-year cumulative incidences of CAD for women receiving left sided RT was10.5%, compared to 5.8% in those receiving right-sided RT. For women diagnosed between ages 25-39 years, those who received left-sided RT had a 5.9% incidence of CAD, while those receiving right-sided RT had no CAD. Women between ages 40-54 years experienced an 18.7% incidence of CAD after undergoing left-sided RT, and 6.8% following right-sided RT. The study was published on September 21, 2021, in JACC: CardioOncology.

“Clinicians caring for younger breast cancer patients should communicate the importance of RT for breast cancer, while explaining the need for long-term attention to the risk of heart disease, particularly for women receiving left-sided radiation therapy,” said lead author Gordon Watt, PhD, a postdoctoral research fellow at MSKCC. “RT is an indispensable part of breast cancer care, and the good news for breast cancer patients is that modern techniques and computerized treatment planning have reduced the amount of radiation that reaches the heart, thereby reducing the risk of developing heart disease.”

Radiation-associated CAD has a latency of at least five years, requiring long-term follow-up of breast cancer survivors. Previous studies in older populations have shown left-sided RT is associated with increased risk of developing CAD, although the level of risk varied between studies. According to the researchers, the risk of heart disease after receiving RT for BC has not been previously evaluated for younger women.

Related Links:
University of Toronto
Memorial Sloan-Kettering Cancer Center



Print article

Channels

Critical Care

view channel
Image: EsoGuard has demonstrated over 90% specificity and 90% sensitivity in identifying Barrett’s Esophagus (Photo courtesy of Lucid Diagnostics)

Biomarker Based Non-Endoscopic Technology Identifies Risk for Esophageal Cancer

Barrett's esophagus (BE) is the benign and treatable precursor condition to esophageal adenocarcinomas (EAC) which is usually diagnosed at an advanced stage and is difficult to treat. Finding BE, a sign... Read more

Surgical Techniques

view channel
Image: Bio-glue enables near-instantaneous gelling, sealing and healing of injured tissue (Photo courtesy of Pexels)

Game-Changing ‘Bio-Glue’ Could End Use of Surgical Sutures and Staple

Tissue adhesive washout and detachment are major issues for medical practitioners and may prove fatal for patients, especially when the separation happens in vital organs like the lungs, liver and the heart.... Read more

Patient Care

view channel
Image: Future wearable health tech could measure gases released from skin (Photo courtesy of Pexels)

Wearable Health Tech Could Measure Gases Released From Skin to Monitor Metabolic Diseases

Most research on measuring human biomarkers, which are measures of a body’s health, rely on electrical signals to sense the chemicals excreted in sweat. But sensors that rely on perspiration often require... Read more

Health IT

view channel
Image: AI can reveal a patient`s heart health (Photo courtesy of Mayo Clinic)

AI Trained for Specific Vocal Biomarkers Could Accurately Predict Coronary Artery Disease

Earlier studies have examined the use of voice analysis for identifying voice markers associated with coronary artery disease (CAD) and heart failure. Other research groups have explored the use of similar... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.