We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




3D Imaging Rapidly Diagnoses Aggressive Prostate Cancer

By HospiMedica International staff writers
Posted on 04 Jan 2022
Print article
Image: Screenshot of two 3D prostate biopsy samples (Photo courtesy of Xie et al/Cancer Research)
Image: Screenshot of two 3D prostate biopsy samples (Photo courtesy of Xie et al/Cancer Research)
Deep-learning (DL) can enable tissue microstructures to be volumetrically segmented to improve prediction of aggressive prostate cancer, according to a new study.

The new technique, called image-translation-assisted segmentation in 3D (ITAS3D), developed at the University of Washington (UW; Seattle, USA), and Case Western Reserve University (CWRU; Cleveland, OH, USA), enables annotation-free, biomarker-based interpretation of glandular features, without requiring immunolabeling. Instead, it implements non-destructive 3D pathology and computational analysis of whole prostate biopsies, which are labeled with a rapid, inexpensive fluorescent analog of standard hematoxylin and eosin staining.

The computational 3D approach was applied to 300 biopsies extracted from 50 archived radical prostatectomy specimens, of which 118 contained cancer. The results showed that 3D features in the prostate cancer biopsies were superior to 2D features for risk stratification, and provided more information on the complex tree-like structure of the glands, thus increasing the likelihood that the computer would correctly predict a cancer's aggressiveness. The study was published on December 1, 2021, in Cancer Research.

“The 3D glandular features in cancer biopsies were superior to corresponding 2D features for risk stratification of low- to intermediate-risk prostate cancer patients based on their clinical biochemical recurrence outcomes,” concluded lead author Weisi Xie, PhD, of UW, and colleagues. “An end-to-end pipeline for DL-assisted computational 3D histology analysis of whole prostate biopsies shows that nondestructive 3D pathology has the potential to enable superior prognostic stratification of prostate cancer patients.”

The microscopic structure of the prostate gland is the basis for prognostic grading by pathologists; however, prostate cancer treatment planning is largely dependent upon examination of core-needle biopsies. Since the interpretation of the convoluted 3D glandular structure via visual inspection of a limited number of 2D histology sections is often unreliable, both under- and over-treatment of such patients is common.

Related Links:
University of Washington
Case Western Reserve University



Print article
IIR Middle East

Channels

Critical Care

view channel
Image: Three dimensional measurement of the all-mesh thermistor (Photo courtesy of Shinshu University)

Ultraflexible, Gas-Permeable Thermistors to Pave Way for On-Skin Medical Sensors and Implantable Devices

On-skin medical sensors and wearable health devices are important health care tools that must be incredibly flexible and ultrathin so they can move with the human body. In addition, the technology has... Read more

Surgical Techniques

view channel
Image: The POINT Kinguide robotic-assisted surgical system has made its debut in the US (Photo courtesy of Point Robotics)

First-Ever Spinal Surgical Hand-Held Robot Makes Worldwide Debut

The world’s first ever hand-held robot framework equipped with a parallel manipulator for orthopedic application has made its worldwide debut in the U.S. Point Robotics MedTech Inc. (Taipei, Taiwan) has... Read more

Patient Care

view channel
Image: The biomolecular film can be picked up with tweezers and placed onto a wound (Photo courtesy of TUM)

Biomolecular Wound Healing Film Adheres to Sensitive Tissue and Releases Active Ingredients

Conventional bandages may be very effective for treating smaller skin abrasions, but things get more difficult when it comes to soft-tissue injuries such as on the tongue or on sensitive surfaces like... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.