We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Detecto

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Injectable Gel Can Help Patients with Brain Tumor Recover After Surgery

By HospiMedica International staff writers
Posted on 09 Aug 2022
Print article
Image: Quanyin Hu’s lab has developed an injectable gel that offers promise for tough-to-treat brain tumors (Photo courtesy of University of Wisconsin–Madison)
Image: Quanyin Hu’s lab has developed an injectable gel that offers promise for tough-to-treat brain tumors (Photo courtesy of University of Wisconsin–Madison)

Like the hardiest weed, glioblastoma almost always springs back - usually within months after a patient’s initial brain tumor is surgically removed. That is why survival rates for this cancer are just 25% at one year and plummet to 5% by the five-year mark. One of the challenges of treating this disease is that surgeons can’t always remove every bit of tumor or glioma stem cells that might linger in the brain. Now, a powerful immunity-boosting postoperative treatment could transform the odds for patients with glioblastoma.

A key characteristic of glioblastoma is the aggressive nature of the tumor cells that infiltrate the surrounding tissues. As a result of this, surgeons are unable to clearly feel the boundaries between the tumor and normal tissue. The surgeons cannot remove as much as possible because all the tissues in the brain are vital. Hence, the tumor comes back again, sharply decreasing the survival rate after treatment. Now, scientists at the University of Wisconsin–Madison (Madison, WI, USA) have developed a hydrogel that can be injected into the brain cavity left behind by the excised tumor. The hydrogel delivery method works well because it completely fills the brain cavity, slowly releases the medicine into the surrounding tissue, and promotes the cancer-killing immune response.

The hydrogel is packed with nanoparticles designed to enter and reprogram certain types of immune cells called macrophages. These immune cells normally clean up infectious invaders in the body, but in the tumor environment, they can change into a form that instead suppresses the immune system and promotes cancer growth. And because of the inflammation created by surgery, these rogue macrophages flock to the surgical site, potentially fueling cancer relapse.

The nanoparticles can engineer the macrophages to target a glycoprotein called CD133, a marker for cancer stem cells. The researchers also added an antibody, CD47, that blocks a “don’t-eat-me” signal to promote macrophages to recognize the cancer cells. The preclinical results in mice models show that the hydrogel treatment successfully generated glioma stem cell-specific chimeric antigen receptor (CAR) macrophages - essentially engineering the immune cells on site to target and kill any lingering glioma stem cells.

If effective in humans, the hydrogel treatment could eliminate the need for postsurgical chemotherapy or radiation, reducing toxic side effects while also improving patient outcomes. The next step is testing the hydrogel in larger animal models and also monitoring long-term efficacy and toxicity beyond the four- to six-month period he previously studied. While the researchers initially focused on glioblastoma, the treatment approach could also be applied to other aggressive solid tumors, including breast cancer.

“It provides hope for preventing glioblastoma relapse,” said Quanyin Hu, an assistant professor in the University of Wisconsin–Madison School of Pharmacy’s Pharmaceutical Sciences Division. “We prove that it can actually eradicate these glioma stem cells, which can eventually prevent the glioblastoma from coming back. We can significantly improve survival.”

“We have a lot of work to do before it can be potentially translated into the clinic, but we feel confident that this is a very promising approach for bringing new hope to patients with glioblastoma so they can recover after surgery,” added Hu. “We hope we can do our work to be able to advance this technology to the clinic.”

Related Links:
University of Wisconsin–Madison 

BMP Whole Blood Analyzer: GEM Premier ChemSTAT
Gold Supplier
SARS-CoV-2 Antigen Rapid Test
RapiSafe SARS-CoV-2 Antigen Rapid Test (Professional use)
New
Antimicrobial Susceptibility Testing Software
MICRONAUT6 Software
New
Clinical Centrifuge
CAPPRondo

Print article
Radcal

Channels

AI

view channel
Image: AI transforms smartwatch ECG signals into a diagnostic tool for heart failure (Photo courtesy of Pexels)

AI-Based Smartwatch Accurately Detects Heart Failure Using ECG Signals

People with a weak heart pump might not have symptoms, but this common form of heart disease affects about 2% of the population and 9% of people over 60. When the heart cannot pump enough oxygen-rich blood,... Read more

Surgical Techniques

view channel
Image: Bioelectric medicine could stem excessive blood loss (Photo courtesy of Pexels)

Wearable Neurostimulation Solution Could Stem Excessive Blood Loss in the OR

A wearable neurostimulation solution focused on lessening excessive blood loss could save precious time for surgical teams in the operating room. A collaboration between Spark Biomedical, Inc.... Read more

Patient Care

view channel
Image: The digital stretcher scales are designed specifically for emergent situations in hospitals and emergency rooms (Photo courtesy of DETECTO)

Portable High-Capacity Digital Stretcher Scales Provide Precision Weighing for Patients in ER

For emergency arrivals into a hospital, time is of the essence for gathering patient weights. Now, digital stretcher scales specifically designed for emergent situations in hospitals and emergency rooms... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Business

view channel
Image: The global visualization instruments for MIS market is estimated to surpass USD 21 billion by 2031 (Photo courtesy of Pexels)

Global Visualization Instruments for MIS Market Driven by Increasing Demand for Endoscopy Procedures

The last few years have witnessed an increase in patient preference for medical surgeries that involve fewer incisions. As a result, the demand for visualization instruments, which aid in achieving improved... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.