We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App


31 Jul 2024 - 02 Aug 2024
02 Aug 2024 - 04 Aug 2024
20 Aug 2024 - 22 Aug 2024

Ingestible Microbiome Sampling Pill to Help Diagnose Wide Range of Health Conditions

By HospiMedica International staff writers
Posted on 14 Jun 2024
Print article
Image: Researchers have made significant advances in ingestible microbiome sampling pill technology (Photo courtesy of Tufts University)
Image: Researchers have made significant advances in ingestible microbiome sampling pill technology (Photo courtesy of Tufts University)

The healthy human gut is home to more than 1,000 species of bacteria, most of which play a beneficial role in digestion and protecting against disease. When the natural balance of these microbes is disrupted, a condition known as "dysbiosis" occurs, which is linked to increased inflammation, and higher susceptibility to infections, and can exacerbate other conditions, including cancer. Research is progressively identifying specific microbiome metabolites that offer protective or beneficial effects against diseases. Traditionally, microbiome sampling has relied primarily on analyzing fecal DNA and metabolites, but this method offers limited insight into the environment upstream of the distal colon, where bacterial species can vary significantly. Now, researchers have made significant progress in the development of a compact device, roughly the size of a vitamin pill that can be swallowed and passed through the gastrointestinal tract to sample the full inventory of microorganisms present there.

Researchers at Tufts University (Medford, MA, USA) who developed the device have made improvements in the previous versions of the pill including switching from a rigid shell to a soft, elastic exterior that makes it easier to swallow, and greatly improving the precision of localized microbiome sampling in the small intestine. The refined version features a 3D-printed, soft elastic shell with sidewall inlets that respond to changes in acidity, opening as the pill enters the small intestine. The pill is equipped with elastic microvalves containing swellable polyacrylate beads that seal the inlets after collecting intestinal content.

The device has been employed in animal testing to gather and analyze samples, completing preclinical characterization and setting the stage for forthcoming human clinical trials. This innovation marks a significant breakthrough in understanding the role of the thousands of microbial species throughout the gastrointestinal tract and their impact on health. It holds promise for advancing research into the connections between resident bacteria and various health conditions. It could also potentially serve as both a diagnostic tool for microbiome adjustments and as a drug delivery system to treat those conditions.

Related Links:
Tufts University

Gold Member
Solid State Kv/Dose Multi-Sensor
Gold Member
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Silver Member
Wireless Mobile ECG Recorder
Vein Finder

Print article


Surgical Techniques

view channel
Image: ImmersiveAR is an FDA-510(k) cleared augmented reality (AR) software (Photo courtesy of 123RF)

Breakthrough AR Surgical System Brings Precision-Enhanced Visualization into the OR

State-of-the-art mixed reality and artificial intelligence (AI) technologies are revolutionizing the field of surgery. Now, a groundbreaking augmented reality (AR) technology platform enables surgeons... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: POCT offers cost-effective, accessible, and immediate diagnostic solutions (Photo courtesy of Flinders University)

POCT for Infectious Diseases Delivers Laboratory Equivalent Pathology Results

On-site pathology tests for infectious diseases in rural and remote locations can achieve the same level of reliability and accuracy as those conducted in hospital laboratories, a recent study suggests.... Read more


view channel
Image: The finalists have been announced for the IHF Awards 2024 (Photo courtesy of IHF)

International Hospital Federation Awards 2024 Finalists Announced

The International Hospital Federation (IHF; Geneva, Switzerland) has announced the finalists of the IHF Awards 2024 after the judges completed scoring entries in all 7 Award categories. The IHF Awards... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.