We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Detecto

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Needle-Like Flexible Imaging Endoscope Could Improve Biopsies

By HospiMedica International staff writers
Posted on 22 Sep 2022
Print article
Image: New endoscope uses bendable GRIN lens for 3D microscopy (Photo courtesy of Harvard Medical School)
Image: New endoscope uses bendable GRIN lens for 3D microscopy (Photo courtesy of Harvard Medical School)

Flexible graded index (GRIN) lens, originally developed for the telecommunications industry, are commonly used to perform fluorescence microscopy approaches that can image deep into tissues. However, the fact that they are rigid components has limited their use clinically. GRIN lenses are silica glass rods with a continuously changing refractive index that focuses light coming through the rod without requiring a separate focusing lens. Since their development about 50 years ago, it has been generally thought that GRIN lenses can only be used as rigid imaging probes. Now, researchers have created a flexible needle-like endoscopic imaging probe that can acquire 3D microscopic images of tissue with its bendability made possible by a new GRIN lens.

The new GRIN lens was developed and incorporated into an endoscopy probe by researchers at the Harvard Medical School (Boston, MA, USA). Experiments showed that the probe’s imaging properties are maintained even when it is bent. In order to explore if it was possible to image through a bent GRIN lens, the researchers custom-designed a GRIN lens 500 microns in diameter and about 100 mm long. The lens’ long, thin shape and its lack of a rigid outer casing give it the flexibility to bend about 10 degrees without breaking. They then incorporated the new GRIN lens into an endoscopic imaging probe and tested it by performing two-photon 3D fluorescence imaging through it.

To simulate the real-world bending that would be experienced deep inside tissues, the lens was positioned vertically and pushed to introduce the type of beam deflection that would be experienced if the probe was used in the working channel of a needle used for a biopsy. The experiment showed that the resolution and signal level did not obviously deteriorate when one end of the probe was displaced laterally by 6 mm. Although further development and testing would be needed to bring the endoscope into the clinic, the device is already finding applications in biomedical research. The researchers are pairing the endoscope with a new type of microdevice to test a method for quickly evaluating the effectiveness of various cancer therapies.

The team’s new microdevices are designed to be implanted directly into a tumor and carry small amounts of up to 20 drugs. To measure the effectiveness of the various drugs without removing any tumor tissue, the researchers insert a GRIN-based endoscope directly into the microdevice where it can be used to image fluorescence signals inside the tumor. Although this setup is currently being studied in mice, it could eventually be used in patients to quickly figure out which treatment options are best for fighting each patient’s specific tumor. To move the probes toward clinical application, the researchers are also working to develop longer bendable GRIN lenses to allow deeper imaging and more flexibility. They also want to enhance the mechanical durability of the optical components using a thin polymer coating that won’t affect flexibility.

“When a traditional biopsy is performed, it represents a single moment in time and can take days to get results back from the laboratory,” said research lead Guigen Liu from Harvard Medical School. “Our bendable imaging probes could shorten the waiting time to minutes and enable new approaches that use imaging to dynamically monitor tissue changes, for instance, how tumors react to treatments over time.”

“The bendable nature of these GRIN probes makes measurements in living subjects, such as animals or human patients, much more streamlined and practical,” added Liu. “It could be useful for precise, minimally invasive microscopy-guided placement of needles and catheters for tissue biopsies and tumor ablation, for example.”

Related Links:
Harvard Medical School 

BMP Whole Blood Analyzer: GEM Premier ChemSTAT
Gold Supplier
Renin Control
Lumipulse Renin Control
New
Plastic Jerricans
Diamond RealSeal Jerricans
New
Molecular Diagnostic STI Test
MOLgen PCR-12 STI

Print article
Radcal

Channels

AI

view channel
Image: AI transforms smartwatch ECG signals into a diagnostic tool for heart failure (Photo courtesy of Pexels)

AI-Based Smartwatch Accurately Detects Heart Failure Using ECG Signals

People with a weak heart pump might not have symptoms, but this common form of heart disease affects about 2% of the population and 9% of people over 60. When the heart cannot pump enough oxygen-rich blood,... Read more

Critical Care

view channel
Image: PATHFAST is a compact immunoanalyzer with superior assay performance (Photo courtesy of PHC Europe)

Benchtop Immunoanalyzer Delivers Lab Quality Results for Cardiology, Intensive Care and Emergency Wards at POC

A compact immunoanalyzer with superior assay performance combines the accuracy of a full-scale lab analyzer with the flexibility of a mobile solution, making it an ideal analysis system for laboratories,... Read more

Patient Care

view channel
Image: The digital stretcher scales are designed specifically for emergent situations in hospitals and emergency rooms (Photo courtesy of DETECTO)

Portable High-Capacity Digital Stretcher Scales Provide Precision Weighing for Patients in ER

For emergency arrivals into a hospital, time is of the essence for gathering patient weights. Now, digital stretcher scales specifically designed for emergent situations in hospitals and emergency rooms... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Business

view channel
Image: The global visualization instruments for MIS market is estimated to surpass USD 21 billion by 2031 (Photo courtesy of Pexels)

Global Visualization Instruments for MIS Market Driven by Increasing Demand for Endoscopy Procedures

The last few years have witnessed an increase in patient preference for medical surgeries that involve fewer incisions. As a result, the demand for visualization instruments, which aid in achieving improved... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.