We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Modifying Intestinal Flora Before Surgery Reduces Postoperative Complications in Colorectal Cancer Patients

By HospiMedica International staff writers
Posted on 06 Feb 2023
Print article
Image: Gut microbiota helps healing in colorectal cancer surgery (Photo courtesy of CRCHUM)
Image: Gut microbiota helps healing in colorectal cancer surgery (Photo courtesy of CRCHUM)

Up to 30% of all patients undergoing colorectal surgery suffer from serious complications due to poor healing of their intestinal barrier. Anastomotic complications cause inflammation, serious infection and cancer recurrence. Researchers have known that certain bacteria aid the development of colorectal cancer by producing toxins which damage colon cells or by promoting accumulation of DNA mutations or intestinal inflammation. A team of scientists has now identified two bacterial strains that directly affect whether or not anastomotic leakage, more commonly known as intestinal leakage, occurs.

To identify these two bacterial strains and facilitate modeling on large volumes of data, scientists at the CHUM Research Centre (CRCHUM, Montreal, Canada) developed the Biorepository for Inflammatory and Neoplastic Diseases of the Digestive Tract. The research biobank contains stool specimens of patients admitted for colorectal cancer who have provided their consent to be used for research purposes.

In a promising study, the researchers demonstrated for the first time in mice that modifying intestinal flora before surgery can reduce postoperative complications in colorectal cancer patients. Modifying the patients’ intestinal flora a few days prior to surgery by using a mix of prebiotics and probiotics could form the basis of a new therapeutic approach, according to the researchers. If such a treatment is continued for several days after the surgery, it could hasten the patients’ return to a healthy intestinal microbiota, reduce their hospital stay, improved their chances of survival and better their quality of life. The researchers are now carrying out additional studies to identify other bacteria associated with intestinal leakage or healing.

“In our study, we show that two bacterial strains detected in the stools of patients with this type of cancer have opposite effects on intestinal healing and therefore on recovery,” said principal author Manuela Santos, a professor at Université de Montréal. “Alistipes onderdonkii kh 33, mostly pro-inflammatory, increases the risk of leakage, while the anti-inflammatory effect of Parabacteroides goldsteinii kh 35 fosters healing.”

“The analysis of patients’ intestinal microbiota showed us that bacterial composition differed depending on the occurrence or not of intestinal leakage,” explained Roy Hajjar, a resident physician and the study’s first author. “Once we transplanted these different microbiota profiles to mice, we found that their risks of postoperative complications varied greatly. Simply put, the composition of the microbiota had a direct impact on their chances of recovery.”

Related Links:
CRCHUM

Gold Supplier
SBRT Phantom with Removable Spine
E2E SBRT Phantom with Removable Spine Model 036S-CVXX-xx
New
Double Roller Pump for Arthroscopy
ARTHRO
New
Data Management System
iDMS
New
Electrical Suction Machine
TR-23CII

Print article
Radcal

Channels

AI

view channel
Image: The WHO has conditionally recommended the use of algorithms in assisting with pediatric tuberculosis diagnosis (Photo courtesy of Pexels)

New Evidence-Based Algorithms Could Improve Diagnosis of Pediatric Tuberculosis

Tuberculosis (TB) continues to be one of the most prevalent causes of death among younger populations worldwide. Research indicates that over 96% of the deadly TB cases in children under the age of 15... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Business

view channel
Image: The demand for endometrial ablation devices is increasing due to rising prevalence of gynecological disorders (Photo courtesy of Pexels)

Global Endometrial Ablation Market Driven by Rising Prevalence of Gynecological Disorders

Gynecological disorders, such as menorrhagia, PCOD, abnormal vaginal bleeding, affect millions of women globally every year and are on the rise. Abnormal Uterine Bleeding (AUB) is the most common disorder... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.