We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Male Partner Age Affects IVF Delivery Rates

By HospiMedica International staff writers
Posted on 20 Jul 2017
Print article
Image: An IVF insemination procedure (Photo courtesy 123rf.com).
Image: An IVF insemination procedure (Photo courtesy 123rf.com).
A new study shows that the cumulative incidence of live birth following in vitro fertilization (IVF) can be appreciably reduced by the fathers increasing age.

Researchers at Beth Israel Deaconess Medical Center (BIDMC; Boston, MA, USA) and Harvard Medical School (HMS; Boston, MA, USA) conducted a study that analyzed almost 19,000 IVF cycles performed at a single center in Boston (MA, USA) between 2000 and 2014. The study population included 7,753 couples. The women were stratified according to four age bands: under 30, 30-35 years, 35-40 years, and 40-42; men were stratified into these same four age bands, with an additional band of 42 and over.

Analysis of the cumulative incidence of live birth revealed no significant decline in cumulative live birth when the women had a male partner the same age or younger. However, women 35-40 years of age significantly benefited from having a male partner under 30, with a nearly 30% relative improvement in cumulative incidence of live birth (70%) compared to women whose partner was 30-35 (54%). Live birth rate was lowest in couples where the female partner was in the 40-42 age range, and in this group the age of the male partner had no impact.

The researchers stressed that female age had a larger effect on fertility than male age. While the effect of female age on fertility is overwhelmingly due to increased rates of chromosomal abnormality, the proposed mechanisms in the effect of male age on pregnancy are more subtle. The effect of female age alone demonstrated a 46% relative decrease from the under-30 to 40-42 age band, while male age alone showed only 20% relative decrease over the same age span. The study was presented at the 33rd annual conference of the European Society of Human Reproduction and Embryology (ESHRE), held during July 2017 in Geneva (Switzerland).

“Increasing male age is associated with a decreased incidence of pregnancy, increased time to pregnancy, and increased risk of miscarriage,” concluded lead author and study presenter Laura Dodge, MD, of BIDMC and HMS. “The mechanisms are unclear, but may include impaired semen parameters, increased DNA damage in sperm, and epigenetic alterations in sperm that affect fertilization, implantation, or embryo development.”

IVF is an assisted reproductive technology (ART) in which an egg is combined with sperm outside the body. The process involves monitoring and stimulating a woman's ovulatory process, removing ova and fertilizing them in the laboratory. The fertilized zygote undergoes embryo culture for 2–6 days, and is then implanted in the same woman's uterus or in a surrogate one, with the intention of establishing a successful pregnancy.

Related Links:
Beth Israel Deaconess Medical Center
Harvard Medical School
Gold Member
12-Channel ECG
CM1200B
Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Information Management System
Innovian Anesthesia

Print article

Channels

Critical Care

view channel
Image: Researchers have developed a novel risk score for cardiovascular complications after bone marrow transplant (Photo courtesy of 123RF)

Novel Tool Predicts Cardiovascular Risks after Bone Marrow Transplantation

Every year, thousands of people undergo bone marrow transplants to potentially cure serious diseases like leukemia, lymphoma, and immune deficiency disorders. While these transplants can be lifesaving,... Read more

Surgical Techniques

view channel
Image: The Early Bird Bleed Monitoring System provides visual and audible indicators of the onset and progression of bleeding events (Photo courtesy of Saranas)

Novel Technology Monitors and Lowers Bleeding Complications in Patients Undergoing Heart Procedures

Bleeding complications at the femoral access site can significantly hamper recovery, affecting the success of procedures, patient satisfaction, and overall healthcare costs. It is crucial for surgeons... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The new eye-safe laser technology can diagnose traumatic brain injury (Photo courtesy of 123RF)

Novel Diagnostic Hand-Held Device Detects Known Biomarkers for Traumatic Brain Injury

The growing need for prompt and efficient diagnosis of traumatic brain injury (TBI), a major cause of mortality globally, has spurred the development of innovative diagnostic technologies.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.