The Biomerix Biomaterial ventral hernia repair mesh feature a proprietary nonresorbable, biointegrative polycarbonate-polyurethane-urea (PCPU) tissue scaffold on one side, designed to facilitate fibrovascular tissue in-growth, and improve wound healing for better clinical outcomes. The middle section of the mesh incorporates knitted polypropylene monofilament fibers for strength, while the other side of the mesh features a resorbable lactide-caprolactone (PLCL) protective film that functions as a barrier to minimize the risk for adhesions during the wound-healing period.

The Biomerix Biomaterial is designed to play a role similar to the body's extracellular matrix (ECM), enabling the healing process through the main phases of inflammation, proliferation, and remodeling. Its function can be important in repair of acute or chronic injuries and defects, where the body is incapable of producing an adequate healing response. Among the benefits of the Biomerix Biomaterial are minimal inflammatory response, robust cellular infiltration and angiogenesis, and development of fibrovascular ECM with no fibrous encapsulation. The Biomerix Ventral Hernia Repair Mesh is a product of Biomerix (Fremont, CA, USA), and has been approved by the U.S. Food and Drug Administration (FDA).

"We believe the novel [biointegrative tissue material] has desirable scaffold features leading to successful repair outcomes, making it a compelling alternative to other synthetic biomaterials,” said Kenneth Hayes, president and CEO of Biomerix.

Urethanes based on polycarbonate, such as PCPU, incorporate soft segments and aromatic isocyanate based hard segments, have been shown to provide superior biostability, due to a native resistance to hydrolytic, oxidative, and enzymatic degradation in vivo. Additionally, since cell migration, proliferation, and attachment into the high surface area are dependent on the surface chemistry and hydrophobicity of the scaffold, the PCPU specific characteristics determine the adsorption sequence and specificity of various plasma and ECM proteins and subsequent cell adhesion to the adsorbed proteins.

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