Features | Partner Sites | Information | LinkXpress
Sign In
Advantech Europe
KOREA E & EX
Schiller

Dentistry Approaching a Major New Treatment Breakthrough

By HospiMedica International staff writers
Posted on 13 Jul 2010
Image: Atomic force microscopy image of the multilayered PGA-alpha-MSH film (photo courtesy INSERM).
Image: Atomic force microscopy image of the multilayered PGA-alpha-MSH film (photo courtesy INSERM).
The next big treatment revolution in dentistry could involve a novel regenerative therapy in which diseased or necrotic pulp tissues are replaced with healthy pulp tissue to revitalize teeth, claims a new study.

Researchers at the Institut National de la Sante et de la Recherche Medicale (INSERM; Strasbourg, France), the University of Montpellier (France), and other institutions reported the development of a multilayered, nano-sized film--only 1/50,000th the thickness of a human hair--that contains alpha melanocyte stimulating hormone (α-MSH), a substance that possesses anti-inflammatory properties in many acute and chronic inflammatory models. When α-MSH was covalently coupled to poly-l-glutamic acid (PGA), the resulting PGA-α-MSH nanofilm retained its anti-inflammatory properties when tested on rat monocytes.

The researchers then incubated PGA-α-MSH with dental pulp lipopolysaccharide (LPS)-stimulated fibroblasts, and were able to show that PGA-α-MSH has potential effects in promoting human pulp fibroblast adhesion and cell proliferation. It can also reduce the inflammatory state of LPS-stimulated pulp fibroblasts, as observed in gram-negative bacterial infections. According to the researchers, these effects suggest a novel use of PGA-α-MSH as an anti-inflammatory agent in regenerative endodontics, the development and delivery of tissues to replace diseased or damaged dental pulp, and could provide a revolutionary alternative to pulp removal in root canal therapy (RCT). The study was reported in the July 2010 issue of the American Chemical Society (ACS) journal Nano.

"It's not like toothpaste, which prevents cavities,” said coauthor Nadia Benkirane-Jessel, Ph.D., of INSERM. "Here we are really trying to control cavities after they develop. Instead of a drill, a quick dab of gel or a thin film against an infected tooth could heal teeth from within.”

According to the researchers, PGA-α-MSH can not only modulate pro- and anti-inflammatory cytokines but can also promote adhesion of pulpal fibroblasts, and could therefore have important regulatory functions in extracellular matrix composition, as well as additional regulatory functions needed to modulate pulpal inflammation and reduce the need for RCT.

Related Links:

Institut National de la Sante et de la Recherche Medicale
University of Montpellier




Channels

Critical Care

view channel

Standard Diagnostic Tests Help Identify Appendicitis

A new study suggests that white blood count (WBC) and polymorphonuclear leukocyte differential (PMN%) can improve the predictive value of ultrasound (US) in children with suspected appendicitis. Researchers at Boston Children’s Hospital (MA, USA) conducted a retrospective cohort study of 845 children who underwent an... Read more

Women's Health

view channel

Nitrous Oxide for Labor Makes US Comeback

Long used for its anxiolytic properties during labor in European countries and Canada, nitrous oxide (N2O) use is resurging in the United States. While in countries such as Norway, New Zealand, Sweden, Australia, and England, usage rates of inhalational N2O during parturition reach 70%, it has only recently become an... Read more

Health IT

view channel
Image: Remote Intelligent Telehealth Assistant (RITA) (Photo courtesy of PR Newswire).

Telehealth Robot Launched to Increase Productivity of Doctors in Clinics and Hospitals

A robot uses high-definition monitors, high-speed components, and wireless communications, and serves as a telehealth media center to give doctors more flexibility in treating and assisting patients remotely.... Read more

Hospital News

view channel

Patient Navigators Help Reduce Emergency Department Visits

Employing patient navigators—nonclinical staff members who connect patients with essential care services—can significantly reduce the overuse of emergency departments (EDs) and the number of hospital readmissions. A pilot program conducted at three hospitals in western Pennsylvania (USA), St. Vincent Health System (Erie,... Read more

Business

view channel

Pfizer to Buy Hospira to Bolster Hospital Products

Pfizer (New York, NY, USA) has entered into a definitive merger agreement with Hospira (Lake Forest, IL, USA), in a move designed to significantly enhance their global established pharmaceutical (GEP) business, for a total enterprise value of approximately USD 17 billion. The strategic complementary combination will... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.