Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Advantech Europe
Ampronix

Allograft Technique Could Repair Traumatic Nerve Injuries

By HospiMedica International staff writers
Posted on 18 Aug 2014
Image: Structure and appearance of the Avance Nerve Graft (Photo courtesy of Axogen).
Image: Structure and appearance of the Avance Nerve Graft (Photo courtesy of Axogen).
A new study describes an innovative nerve repair technique that yields better results and fewer side effects than current existing techniques.

Researchers at the University of Kentucky (UKY; Lexington, USA) and the Buncke Clinic (San Francisco, CA) conducted a study to compare 41 subjects with 55 with nerve gap injuries that were repaired with either a nerve allograft (34 subjects), nerve tube conduit (13 subjects), or nerve autograft (8 subjects). Demographics, medical history, and associated injuries were comparable between treatment groups. Response to treatment was defined as improvement from baseline, with independent blind observers determining the degree of sensory or motor recovery.

The results showed that the average nerve gap between the groups varied, at 24±12mm, 11±4 mm, and 57±30mm for processed nerve allograft, conduit, and nerve autograft respectively. Available data reported meaningful levels of recovery in 80% of nerve allografts, as compared to 43% of tube conduits. There were no reported adverse events related to the treatment groups. The study results were presented at the annual combined meeting of the American Association for Hand Surgery, the American Society of Reconstructive Microsurgery, and the American Society of the Peripheral Nerve, held in January 2014 in Kauai (HI, USA).

“The results of the study suggested that nerve allografts had more consistent results and produced better outcomes than nerve conduits, while avoiding the donor site morbidity of a nerve autograft,” said study presenter and coauthor Brian Rinker, MD, Of the UKY Hand Surgery Service. “Nerve grafting has remained relatively unchanged for nearly 100 years, and both of the existing nerve repair options had serious drawbacks. The new technique provides a better, more predictable, and safer nerve gap repair compared to the previous techniques.”

The nerve allograft used in the study was the Avance Nerve Graft, a product of AxoGen (Alachua, FL, USA), and is derived from human nerves harvested from cadavers, which are processed to remove all cellular material, thus preserving their architecture while preventing disease transmission or allergic reactions. Future nerve allografts could be engineered to include growth factors which would guide and promote nerve regeneration, theoretically leading to even faster recoveries and better results.

Related Links:

University of Kentucky
Buncke Clinic 
AxoGen



Anetic Aid
ECR
Cincinnati Sub-Zero

Channels

Women's Health

view channel

Maternal Iron Intake Linked to Autism Risk

A new study reveals that mothers of children with autism spectrum disorder (ASD) are less likely to have taken iron supplements before and during their pregnancies. Researchers at the University of California Davis (UCD; USA) and the UCD Mind Institute Clinic (Sacramento, CA, USA) analyzed data from 866 mother-child... Read more

Health IT

view channel

Doctors Claim EHRs Do Not Save Money or Time

A recent survey claims that 75% of physicians in the United States who use electronic health records (EHRs) say they are not cost- or time-effective, but do have value in terms of providing data. The Deloitte (New York, NY, USA) 2014 Survey examined US physicians’ current use and overall views of mobile health (mHealth)... Read more

Hospital News

view channel

Apollo Hospitals Opens New Diabetes Clinics

Apollo Hospitals (Kolkata, India) has partnered with pharmaceutical giant Sanofi (Paris, France) to improve access to treatment for diabetics. The joint venture, to be named Apollo Sugar Clinics, will be a subsidiary of Apollo Health and Lifestyle, with Sanofi proposing to buy a 20% stake. For the first phase of the... Read more

Business

view channel

Growth Expected for Global Patient Monitoring Market

The global advanced patient monitoring market has benefited from demand at health facilities and in the home treatment markets. These are the latest findings of Kalorama Information (New York, NY, USA), an independent medical market research firm. The global advanced patient monitoring market includes equipment and devices... Read more
 

Events

23 Oct 2014 - 26 Oct 2014
12 Nov 2014 - 15 Nov 2014
Copyright © 2000-2014 Globetech Media. All rights reserved.