Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Ampronix

Events

11 May 2016 - 14 May 2016
16 May 2016 - 18 May 2016

Innovative Wound Dressing Wraps Burn Wounds

By HospiMedica International staff writers
Posted on 27 Aug 2014
Print article
Image: PLLA biodegradable polyester nanosheets (Photo courtesy of Tokai University).
Image: PLLA biodegradable polyester nanosheets (Photo courtesy of Tokai University).
A new nanometric biomaterial coating hugs body contours like cling-wrap, preventing bacteria from colonizing wounds.

Researchers at Tokai University (Tokyo, Japan) developed the nanosheets from poly-L lactic acid (PLLA), a biodegradable polyester that when centrifuged with water breaks up into small pieces. When poured onto a flat surface, the PLLA emulsion dries into a patchwork that forms as a single nanosheet. The researchers then tested the nanosheets’ ability to coat small and irregular shapes by dipping various objects into the mixture, including a mouse’s paw. The nanosheet patchwork effectively covered the surface of the mouse’s digits, and after it dried, it clung in place.

The researchers then tested the nanosheets on burn wounds, and found that the PLLA dressing could protect wounds against the common bacteria Pseudomonas aeruginosa for three continuous days. With an additional coating, the nanosheets kept bacteria at bay for a total of six days, which suggests that its use could also reduce the number of dressing changes needed. In preparation for projected human clinical trials, the researchers are currently planning large-scale animal and safety tests.

In addition to PLLA nanosheets, the researchers have recently started developing a novel set of similar, super-flexible, patchwork coatings composed of polymers with a phosphorylcholine group, a range of materials that are compatible with blood and could thus act as coatings for medical devices, such as catheters. The study describing nanosheets and its application as a burn wound dressing was presented at the national meeting & exposition of the American Chemical Society (ACS), held during August 2014 in San Francisco (CA, USA).

“Existing wound dressings work well when it comes to treating burns on relatively flat and broad areas. But the human body has curves, wrinkles and ridges that present problems for these dressings,” said lead author and study presenter Yosuke Okamura, PhD. “The nanosheets can adhere not only to flat surfaces, but also to uneven and irregular surfaces without adding any adhesives.”

PLLA is a biodegradable, thermoplastic, aliphatic polyester derived from renewable resources, such as corn starch, tapioca roots, or sugarcane. It can be processed by extrusion, injection molding, casting, and spinning, providing access to a wide range of materials. Since it is biodegradable, PLLA is used as medical implants in the form of anchors, screws, plates, pins, rods, and as a mesh, breaking down inside the body within 6 months to 2 years.

Related Links:

Tokai University



Print article
Radcal
Barco

Channels

Women's Health

view channel

Suboptimal Weight Affects Survival in Cervical Cancer

Both overweight and underweight women with cervical cancer did not live as long as their normal-weight counterparts, according to a new study. Researchers at the University of Cincinnati (OH, USA) and the University of North Carolina (UNC; Chapel Hill, USA) conducted a retrospective cohort study of 623 women with cervical... Read more

Hospital News

view channel

Mikkeli Central Hospital to Undergo Major Modernization

The European Investment Bank (Luxemburg; EIB) has provided a long-term loan of € 55 million to the South Savo Social and Health Care Joint Authority to renovate and extend the Central Hospital campus in Mikkeli (Finland). The campus, situated in the center of the 55,000 municipality, will undergo a renovation and extension... Read more

Business

view channel

Mobility Aids Equipment Market to Experience Rapid Growth

The global market for mobility aids and transportation equipment market is estimated to reach USD 7.8 billion by 2021. These are the latest findings of IndustryARC (Hyderabad, India), an international research and consulting firm. Mobility equipment for the incapacitated, disabled and seniors is comprised of a large... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.