New Optoacoustic Technique Reveals Activation of Large Neural Circuits

Optoacoustics uses short laser pulses to cause short-term expansion of tissue that leads to very small ultrasound vibrations that are detected, registered, processed and converted into 3D images. The researchers showed that it was fundamentally possible to track neural dynamics and neural activity in the brain of the zebrafish directly even during unrestrained motion of the zebrafish.

Study leader Razansky, said, "Thanks to our method, one can now capture fast activity of millions of neurons simultaneously. Parallel neural networks with the social media: in the past, we were able to read along when someone (in this case, a nerve cell) placed a message with a neighbor. Now we can also see how this message spreads like wildfire. This new imaging tool is expected not only to significantly promote our knowledge on brain function and its pathophysiology but also accelerate development of novel therapies targeting neurological and neuropsychiatric disorders."

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