Advanced Imaging Aids Treatment of Lymphatic Plastic Bronchitis

The researchers then treated six of the seven with lymphatic embolization, using a combination of endovascular glue and coils.

After lymphatic embolization, five of the patients reported immediate and complete resolution of symptoms, and the sixth patient reported significant partial improvement. Four patients had transient abdominal discomfort, which was treated with analgesics and resolved before discharge in all subjects. The average follow-up period was 11 months after initial treatment. The study was published in the October 2016 issue of Annals of the American Thoracic Society.

“Based on these data, we postulate that many cases of idiopathic plastic bronchitis in adults have a lymphatic basis, and propose that the diagnosis be renamed ‘lymphatic plastic bronchitis’ in those subjects, to distinguish the disorder from the other forms,” concluded lead author radiologist Maxim Itkin, MD, of CHOP. “Percutaneous transabdominal catheterization and embolization of the pulmonary lymphatics is a safe and effective treatment for the acute manifestation of this disorder, but additional studies are needed to determine the long-term safety and durability of this approach.”

Plastic bronchitis is a condition characterized by expectoration of branching bronchial casts. Although the mechanism of cast formation in adults with plastic bronchitis remains poorly understood, abnormal pulmonary lymphatic flow resulting in molding of congealing lymphatic fluids in the airway can cause life-threatening respiratory distress, especially in children. In adults, the condition may go undiagnosed for years in patients who may initially be diagnosed with asthma or chronic cough.