Advanced Scanner Produces Whole-Body PET Images in Seconds

By combining eight scans into one, total body rendering can be accomplished in 1/40 of the time of a conventional PET scanner, as well as using 1/40 of the radiation dose.

The modified PET scanner, which is called Explorer, could be especially helpful for imaging children, who tend to move around inside a scanner and ruin the measurements, as well as in pharmacological studies that examine how a radioactive tracer spreads through the body. For example, the device could be used with a radioactive sugar tracer that is ingested by bacterial, but not mammalian cells. Other types of tracers could be used to distinguish between different bacteria. The capabilities of Explorer were shown at the US National Institutes of Health (NIH) High-Risk, High-Reward research symposium, held during June 2019 in Bethesda (MD, USA).

“The level of detail was astonishing, especially once we got the reconstruction method a bit more optimized. We could see features that you just don't see on regular PET scans,” said Explorer presenter Ramsey Badawi, MD, chief of nuclear medicine at UCD and vice-chair for research in the department of radiology. “The dynamic sequence showing the radiotracer moving around the body in three dimensions over time was, frankly, mind-blowing. There is no other device that can obtain data like this in humans, so this is truly novel.”

PET scans are widely used to diagnose and track a variety of diseases, including cancer, because they show how organs and tissues function in the body, in contrast to MRI or CT scans, which mostly show anatomy. Using radioactive tracers that produce a signal from within the body, PET scanners produce a 3D image that is constructed by computers using sophisticated mathematical techniques. The Explorer project was designed to address the shortcomings of current scanning technology, which requires more time and exposes the patient to more radiation because scans are done in small segments.

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