New Virus Caused Deaths of Transplant Recipients

Knowledge of genetic sequence of the virus will enable improvements in screening to enhance transplantation safety.

Scientists in the Greene Infectious Disease Laboratory of the Columbia University Mailman School of Public Health (New York, NY, USA) and colleagues in the Victorian Infectious Diseases Reference Laboratory in Melbourne (Australia) and 454 Life Sciences (Branford, CT, USA) have discovered a new virus that was responsible for the deaths of transplant recipients.

The previously unknown virus, which is related to lymphocytic choreomeningitis virus (LCMV), was found using rapid sequencing technology established by 454 Life Sciences and bioinformatics algorithms developed in the Greene Laboratory with support from the US National Institute of Allergy and Infectious Diseases. Known strains of LCMV have been implicated in a small number of cases of disease transmission by organ transplantation, however, the newly discovered virus is sufficiently different that it could not be detected using existing screening methods.

Over 30,000 organ transplants are performed in the United States each year. Knowledge of the genetic sequence of this virus will enable improvements in screening that will enhance the safety of transplantation.

Ian Lipkin, M.D., director of the Greene Laboratory and lead investigator of the Northeast Biodefense Center, emphasized the importance of academic, public health, and industrial partnership in this work. This was a team effort. Drs. Mike Catton and Julian Druce at the Victorian Infectious Disease Reference Laboratory reached out to us after a comprehensive state-of-the-art investigation failed to turn up leads, stated Dr. Lipkin. We succeeded in identifying the virus responsible for the deaths by building on their work and utilizing new tools for pathogen surveillance and discovery developed in the Greene Laboratory and 454 Life Sciences.


Related Links:
454 Life Sciences
Greene Infectious Disease Laboratory
Victorian Infectious Diseases Reference Laboratory