Comparing MRI, CT, and Radiography for the Detection of Bone Erosion in Arthritic Wrists

The early detection of bone erosions is critical for identifying those individuals most at risk from RA.

Dr. Uffe Møller Døhn, from the Copenhagen University Hospital (Hvidovre, Denmark), and co-workers performed CT, MRI, and radiography on the wrist joints of 17 RA patients and 4 healthy controls.

Taking CT as the reference method for detecting bone erosions, radiography and MRI both showed good specificity (99% and 93%, respectively) but radiography showed low sensitivity (24%) compared to the moderate sensitivity (61%) of MRI. They also found that there was strong agreement between the CT and MRI measurements of erosion volumes. The measured volumes also correlated closely with the Outcome Measures in Rheumatology (OMERACT) erosion scores, thus validating this scoring method further.

The researchers reported that the results show that CT may be useful for detecting and monitoring bone erosion in RA. Dr. Møller Døhn stated, "The number of erosions detected on CT indicate that CT is a very sensitive method for detecting bone erosions in RA wrist bones, possibly even more sensitive than MRI.” However, he acknowledged that the technique's sensitivity to change was not yet established and that its use of ionizing radiation and inability to detect soft tissue changes did count against it.


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