CT Lung Cancer Screening No Panacea for Smokers

The recent research was published in the July 2008 issue of the journal Radiology. "Our study suggests that screening may be one way to reduce risk of death from lung cancer,” said the study's lead author, Pamela McMahon, Ph.D., a senior scientist from Massachusetts General Hospital and instructor in radiology at Harvard Medical School (both in Boston, MA, USA). "However, the number-one goal should still be to quit smoking, because it will reduce risk of death from many causes, including lung cancer.”

For the study, researchers from Harvard and the Mayo Clinic (Rochester, MN, USA), set out to determine the long-term effectiveness of CT screening for lung cancer by entering data from Mayo's helical CT screening study of 1,520 current and former smokers into the Lung Cancer Policy Model (LCPM), a comprehensive simulation model of lung cancer development, screening findings, treatment results, and long-term outcomes. Using the model allowed researchers to interpret available data while waiting for long-term randomized clinical trials to be completed.

"We used a carefully developed computer model of lung cancer to simulate individuals who smoke and/or develop lung cancers and go on to get screened or treated,” Dr. McMahon said. "It's sort of like the computer game ‘The Sims,' except there are no graphics, and smoking and lung cancer are the main events.”

The LCPM projections showed that, at six-year follow-up, the patients who had undergone five annual screenings had an estimated 37% relative increase in lung cancer detection, compared with those who had not been screened. The relative reduction in lung cancer-specific mortality was 28%. However, reduction in all-cause mortality was only 4%. Fifteen-year follow-up showed relative reductions in lung cancer-specific mortality of 15% and all-cause mortality of 2%.

"Our study fills in a piece of the puzzle but does not solve it,” Dr. McMahon said. "We are hopeful that randomized trials conducted by the [U.S.] National Cancer Institute will show a benefit from screening. Until then, patients should think carefully about undergoing a test that has no direct evidence of benefit.”


Related Links:
Massachusetts General Hospital
Mayo Clinic