Molecular Imaging Probes Pinpoint Prostate Cancer

New research demonstrates how an innovative peptide-targeted imaging agent could help clinicians detect a biologic process that signals cancer in prostate cells. Data gathered about this process may even differentiate prostate tumor types and the progression of disease.

"This new molecular imaging tool will help us develop new diagnostic and therapeutic options for prostate cancer patients,” said Chiun-Wei Huang, Ph.D. candidate, lead author, and researcher at the Molecular Imaging Center of the Keck School of Medicine, University of Southern California (Los Angeles, CA, USA). "By identifying a signature on the cell-surface of specific tumor types at different stages, we could potentially develop better and more customized treatments for truly personalized medicine.”

In this study, researchers used near-infrared fluorescent imaging, an optical imaging technique that images the low frequency light emitted from an imaging agent containing fluorescent dye. The novel agent used in the study was prepared with a peptide that targets receptor activity involved in the prolific growth of certain tumor cells. This specific sequence of receptor activity is called a2ß1 integrin, an expression of building-block proteins such as collagen. Cells that display an abnormal over-abundance of this activity could be cancerous, and imaging that focuses on this biologic mechanism could provide vital information about the aggressive growth, survival, migration, and invasiveness of individual cases of prostate cancer.

The study's findings revealed that high absorption of the peptide-targeted agent positively identified prostate tumors both in the laboratory and in three prostate tumor-bearing models. Further development of this and similar imaging agents could lead to more effective and detailed diagnosis of prostate cancer and it could be used to test the effectiveness of new drug therapies to treat the disease.

The study's findings were presented at the Society of Nuclear Medicine's (SNM) 57th annual meeting, June 5-9, 2010, in Salt Lake City, UT, USA.

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Keck School of Medicine, University of Southern California