Partnership to Develop New MR-Guided Radiation Therapy Technology

(Palo Alto, CA, USA) and Imris, Inc. (Winnipeg, Manitoba, Canada) have concluded an agreement to codevelop an innovative magnetic resonance imaging (MRI)-guided radiation therapy system for use in treating a range of cancers.

Under the terms of the agreement, the two companies will develop a solution that combines Imris's proprietary MR imaging technology with Varian's recently introduced TrueBeam system, to enable the use of MRI during radiotherapy treatments for cancer. Launched in April 2010, Varian's TrueBeam system for radiotherapy and radiosurgery offers speed and accuracy and has the ability to deliver treatments up to 50% faster, with a dose delivery rate of up to double the maximum of earlier, industry-leading Varian systems.

MR is the gold standard for soft tissue imaging. By utilizing Imris's proprietary technology and integrating the detail of MR imaging with the extensive treatment delivery capabilities of the TrueBeam system, the two companies expect to enhance the effectiveness of radiation therapy. "We are seeking to augment physicians' ability to target cancerous tissue very precisely, even in areas of the body that are difficult to image,” said Dow Wilson, president of Varian's oncology systems business. "Many studies have shown that increased treatment accuracy can reduce the impact on healthy tissues around a targeted tumor.”

The solution will be designed to permit a high-field MRI scanner to move in and out of the radiation therapy room on demand, providing MR imaging to very precisely identify a tumor's location prior to treatment, and again during the session as needed, all without having to move the patient from the treatment couch or transport the patient to and from another room, as would be required today. Consistent with Imris's systems for neurosurgery, neurovascular, and cardiac applications, the radiation therapy systems are expected to be offered as multiroom configurations and include independent MR-simulation capabilities for the MR system to additionally enhance cost-effective utility for hospitals.

Imris first began development of its MR-guided radiation therapy program in 2008 in collaboration with the University Health Network (UHN) in Toronto, Canada. A state-of-the-art Imris 3T MR-simulation suite was installed in 2009 at UHN's Princess Margaret Hospital (Toronto, Canada). Princess Margaret Hospital (PMH) will complement the development work by Varian and Imris by providing the clinical expertise and environment for building and testing the first of these systems.

Dr. David Jaffray, head of radiation physics at PMH said, "There are certain clinical situations that challenge even the most advanced methods available for targeting cancer. Tightly integrating MR imaging into radiation treatment will allow us to adapt the therapy to the individual patient and will open exciting new avenues of research to further improve the effectiveness of radiation therapy.”

Following successful completion of the development stage of this project, and subject to necessary regulatory approvals, the companies anticipate co-branding the new MR-guided radiation therapy suite and leveraging Varian's global presence and leadership position in the fields of radiotherapy and radiosurgery to market the new product.

"More than 10 million new cancer cases occur throughout the world each year, and in the U.S., about half of all cancer patients receive some type of radiation therapy during the course of their treatment,” said David Graves, chairman and CEO, Imris. "By combining Imris's image-guided capabilities with the scale and scope of Varian's operations we have a significant opportunity to accelerate time to market and extend the benefits of MR imaging to radiation treatment rooms around the world.”

Related Links:
Varian Medical Systems
Imris