Targeted MRI to Transform Imaging Market

"The development of targeted MRI contrast agents that are directed to specific molecular entities could dramatically expand the range of MRI market applications by combining the noninvasiveness and high spatial resolution of MRI with the specific localization of molecular targets,” said Joe Constance, Kalorama analyst and author of the report. "The technologies have the potential to make imaging definitive for a range of clinical applications such as the detection of tumors and heart disease.”

Targeted imaging involves adding special molecules to imaging agents that can attach directly to specific molecular entities. The application combines the effectiveness of a contrast agent with an adhesion molecule in order to target the contrast directly to the desired target. The imaging approach differs depending on whether the target is a single disease control point (a specific receptor or transport protein tied to the mechanistic activity of a drug) or a general disease control point applicable to a number of treatment paradigms (proliferation, angiogenesis, or inflammation).

Currently, there are no targeted MRI contrast agents available for specific imaging of tumor and cardiovascular diseases, but many MRI applications are under development, according to the report. However, several targeted SPECT imaging agents are available for clinical applications. Because of the fundamentally low sensitivity of MRI, in comparison with nuclear imaging, high concentrations of the contrast agent at the target site would be required, along with high affinity and specificity of cell recognition.

Scientists have successfully targeted MRI and nuclear medicine contrast agents to the alpha-V/beta 3 integrin, permitting noninvasive monitoring of angiogenesis.

In some instances, the targeted approach may require the use of less contrast. Differential contrast in soft tissues depends on endogenous differences in water content, relaxation times, or the diffusion characteristics of the tissue of interest. Gadolinium chelates, for example, have been successfully used for imaging hemodynamic parameters, including blood perfusion and vascular permeability.

Kalorama estimated the 2010 market for all contrast media at over US$7.5 billion. The firm sees realistic growth rates based on existing market conditions, but noted that a trend such as targeting agents could considerably increase revenue potential for companies in this industry.

Kalorama Information supplies independent market research in the life sciences, as well as a full range of custom research services.

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