CT Angiography Screening in Asymptomatic Patients Without Apparent Benefit

However, the usefulness of the imaging modality on low-risk patients who do not have coronary symptoms, such as chest pain, has been unclear.

In the first large population study to assess the impact of the test on physicians and patients, Johns Hopkins University (JHU; Baltimore, MD, USA) cardiologists discovered that having CT angiography leads to more prescriptions for cholesterol-lowering medications and aspirin, as well as more stress tests, nuclear medicine scans, and invasive catheterizations. However, the incidence of heart attacks or cardiac death among the study participants was the same, whether or not patients had a CT angiography test.

"There was no difference in cardiac events at 90 days or at 18 months between the group that had positive findings on the CT angiogram screening compared to the group that did not have the test," said John W. McEvoy, MB., BCh, BAO, a Johns Hopkins heart specialist and lead author of the study. "Our findings suggest that low-risk patients without symptoms don't benefit in the short term from knowing whether or not plaque has been detected using CT angiography. However, their physicians may be inclined to be more aggressive with prescriptions or follow up tests."

For the study, published online in the journal Archives of Internal Medicine on May 23, 2011, researchers compared two similar groups of 1,000 asymptomatic patients who were taking part in a health-screening program in South Korea. Patients in one of the groups had coronary CT angiography while a matched control group of 1,000 patients did not have the test. The baseline heart disease risk factors were the same in both groups and none of the patients had chest pain or other symptoms. The mean age of the participants was 50, and 63% were men. All were given the standard of care and were advised on ways to lower their risk.

Of the 1,000 patients who had CT angiography, 215 had a positive result, meaning that waxy plaque deposits were seen in their vessels. As a result, they were much more likely to have more aggressive care, according to the study findings. After 18 months, the patients with plaque detected on the test were 10 times more likely to have been sent for an exercise stress test, a nuclear medicine scan, or a cardiac catheterization, compared with those patients who didn't have the test. Moreover, they were three times more likely to be taking a statin medication and four times more likely to be on aspirin therapy.

After 18 months, one person in the CT angiography group developed unstable angina, while one person in the control group had a fatal heart attack. "Our data are consistent with current guidelines by the American Heart Association that screening CT angiography should not play a role for low-risk patients who do not have symptoms," said Roger Blumenthal, MD, a coauthor of the study who is a professor of medicine and director of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease. "Before we advocate for a particular screening test, we need to demonstrate its potential benefit and define the patient populations for whom the test would be useful." Dr. Blumenthal reported that a CT angiography test could cost between US$600 and $1,000.

Johns Hopkins heart specialist Michael Blaha, MD, MPH, a coauthor on the study, stresses that the findings of the study only apply to individuals believed to be at low risk of cardiovascular events, such as a heart attack, in the next 10 years. "There does seem to be a role for CT angiography in patients who have chest pain, particularly in the emergency room setting. There, CT angiography offers the opportunity to exclude atherosclerosis as the cause of the symptoms, which can be very helpful in the triage of patients," Dr. Blaha stated.

The senior author of the study, Hyuk-Jae Chang, MD, PhD, is a cardiologist at the Yonsei University Health System (Seoul, South Korea), whose large data set was used in the study. He had asked Dr. Blumenthal to collaborate on the research. "This was a unique opportunity to analyze the data and look at the downstream impact of the test on physicians and patients," remarked Dr. Blumenthal.

CT angiography is different from calcium scoring, which has been established as a useful way to assess risk among people with an intermediate risk of a heart attack within 10 years. CT angiography is a more accurate test than calcium scoring, showing not just calcified areas of plaque in heart arteries but also the fatty deposits that form earlier and have not hardened yet. However, CT angiography requires an injection of contrast material, delivers more radiation than calcium scoring, and is more expensive.

In a commentary accompanying the article, Michael S. Lauer, MD, from the US National Heart, Lung and Blood Institute (Bethesda, MD, USA), stated that the study serves as a powerful reminder that testing without evidence of a benefit "can lead to exposure to further medical tests and treatments, each of which carries its own risk. We cannot simply assume that just because a screening test predicts clinical outcomes, interventions necessarily will prevent them," Dr. Lauer added in his commentary.

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Hopkins University
Yonsei University Health System