Invasive Ventroculography May Be Greatly Overutilized

The investigators found that it is routinely performed as an add-on procedure during a coronary angiogram, a separate heart-imaging modality, at an added cost of USD 300.

Over the years, several less-invasive and often superior methods of measuring ejection fraction have emerged, such as echocardiograms and nuclear cardiac imaging, making the use of left ventriculography problematic at times, the study authors reported.

The study was published online April 2012 in the American Heart Journal. Several years ago when Dr. Witteles was a cardiac fellow, he and his colleagues noticed a great degree of variation in whether cardiologists would order the procedure, often in similar patient cases. This seemingly arbitrary use of left ventriculography led to the conception for this study.

Researchers first tried to determine precisely how frequently the procedure was conducted. They searched a US database of around 96,000 patients enrolled in Aetna (Hartford, CT, USA) health benefits plans in 2007 who underwent a coronary angiogram during that year. The data revealed left ventriculography was performed 81.8% of the time whenever an angiogram was performed--an amazingly high rate, according to Dr. Witteles.

Next, they wanted to find out how high that figure was in a population of patients for whom it would almost never be medically justified to perform the procedure. So they looked at those patients who had very recently--within the 30 days prior to having a coronary angiogram-- undergone another imaging study that would have given practitioners the same, and typically better-quality, data. (They excluded patients who had intervening diagnoses of new problems during those 30 days, such as heart failure, shock, or heart attack. Among the remaining 37,000 patients, the researchers found that not only did the majority still get the unnecessary left ventriculography procedure, but also the rate actually leaped to 88%.

“If a patient recently had an echocardiogram or a nuclear study, it didn’t make them less likely to have the left ventriculography procedure--it made them more likely,” Dr. Witteles said. “That is impossible to explain from a medical justification standpoint. It is extremely unusual, in these types of cases, to need another assessment. The only logical conclusion is that a practice pattern is being defined in which tests beget more tests, whether they’re necessary or not. It would be bad enough if the figure stayed at 81%, but our findings showed that it went up.”

Even more worrying than the extra costs are the medical risks from performing an unwarranted procedure. For left ventriculography, this can include side effects from injecting contrast dye (which can be particularly hazardous for patients with kidney dysfunction or diabetes), increased radiation exposure, and an increased risk of abnormal heart rhythms and stroke.

During a coronary angiogram, a catheter is threaded through the blood vessels to the heart, contrast dye is inserted, and X-rays are taken. The add-on left ventriculography procedure involves moving the catheter across the aortic valve of the heart and inserting another dose of contrast dye. This allows visualization of the left ventricle and its contractions.

“The biggest downside is that the catheter goes across the valve into the heart,” Dr. Witteles said. “There’s always a risk of dislodging a blood clot, causing a stroke. The procedure only takes five minutes, but it increases the risk of arrhythmias. And then there is the added cost. But the real big-picture issue is how often an unnecessary, invasive test is being routinely ordered.”

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Stanford University School of Medicine