Revised Mammography Guidelines Result in Under Diagnosis

Routine screening mammography has typically been recommended by both the US Preventive Services Task Force (USPSTF; Rockville, MD, USA) and the American Cancer Society (Atlanta, GA, USA) for all women over the age of 40. In 2009, the USPSTF issued divisive new guidelines recommending routine screening with mammography every two years for women 50 to 74 years old. In the studies being presented at RSNA 2012, researchers analyzed the impact of the new guidelines on women between the ages of 40 and 49 and the US Medicare population.

“Recommendations on screening mammography are extremely important public policy and we wanted to contribute to that dialogue,” said Elizabeth Arleo, MD, assistant professor of radiology at New York-Presbyterian Hospital -Weill Cornell Medical College (New York, NY, USA; ). “We get questions all day long from patients and referring physicians on the appropriateness of screening mammography. The inconsistent information is very confusing for everyone.”

For her study, Dr. Arleo and a team of researchers analyzed data on screening mammography at New York-Presbyterian Hospital-Weill Cornell Medical College between 2007 and 2010. Over the four years, 43,351 screening exams were performed, which led to the detection of 205 breast cancers. “Nearly 20% of cancers detected with screening mammography were found among women in their 40s, Dr. Arleo said. “It seems unacceptable to potentially miss nearly 20% of the breast cancers we are identifying. This, in our view, would represent a substantial degree of under-diagnosis.”

Of the women screened in the study, 14,528, or 33.5%, were between the ages of 40 and 49. Of the 205 breast cancers detected, 39 (19%) were found in the 40-49 age group. Of those cancers, more than 50% (21 of 39) were invasive. Only three of the women between the ages of 40 and 49 diagnosed with cancer had a first-degree relative with premenopausal cancer. “Our data favor the American Cancer Society recommendations of annual mammograms starting at age 40,” Dr. Arleo said.

In the second study, another group of researchers analyzed data from The Medicare Part B Physician/Supplier Procedure Summary Master Files for 2005-2010. They calculated the following annual utilization rates for screening mammography per 1,000 female Medicare beneficiaries: 2005, 311.6; 2006, 312.4; 2007, 316.2; 2008, 320.1; 2009, 322.9; and 2010, 309.1.

The compound annual growth rate (CAGR) from 2005 to 2009 for screening mammography utilization was 0.9%, compared to a 4.3% falloff in the utilization rate from 2009 to 2010. “There was considerable controversy over the task force guidelines, but it was unclear how much they would influence women’s choices about screening,” said David C. Levin, MD, professor and chairman emeritus of the department of radiology at Thomas Jefferson University Hospital (Philadelphia, PA, USA). “We’re not able to tell from the data whether this significant drop in utilization was a result of women deciding to wait another year to have their mammogram, or women over the age of 74 not having the exam. But, clearly, the new USPSTF guidelines have had an effect.”

Dr. Levin reported that the decline in the utilization rate of mammography is especially concerning, given that the 2009 rate of 322.9 per 1,000 women was not exceptionally high. “We’ll never see 1,000 out of 1,000 women getting a screening mammogram, but you’d like to see that number closer to 1,000, and certainly higher than 322,” he said. “We need to continue to follow these numbers and to watch the breast cancer mortality statistics.”

Related Links:
US Preventive Services Task Force
American Cancer Society