MRI-Ultrasound Fusion Software Helps with Prostate HIFU Therapy

This application has the potential to support new tissue-preserving treatments for prostate cancer, such as focal therapy.

In the study, researchers from University College London (UCL; UK) examined the possibility of using a computer-assisted, deformable image registration software to enable three-dimensional (3D), multiparametric MRI-derived information on tumor location and extent to inform both the planning and treatment phase of focal high-intensity, focused ultrasound (HIFU) therapy using SonaCare Medical’s (Charlotte, NC, USA) Sonablate 500 ultrasound system. The study’s findings were published in the August 2013 issue of British Journal of Urology International.

This pilot study, positioned within the multicenter INDEX Trial, employed computer-assisted MRI-US image registration software within the planning of the first 26 men with a MRI-visible tumor treated at UCL with HIFU using a tissue-preserving quadrant, hemispheric (hemi) or extended hemiablation therapy. The findings demonstrated that the software, developed at UCL, enables tumor location data to be used for therapy planning using the Sonablate 500 system without adding substantial extra time to the conventional procedural workflow. Such planning is particularly significant for new tissue-preserving treatment approaches to ensure that the tumor is completely treated.

“Multiparametric MRI has shown promise as an accurate method for determining the focality of tumors, and has promise as a potentially important enabler for minimally invasive, tissue-preserving, or focal, HIFU treatments. However, most ablative technologies for localized prostate cancer use an ultrasound platform to plan and deliver treatment, on which the tumor cannot be accurately localized. This often results in discrepancies between the tumor and target volumes, potentially leading to under-treatment at the margins, or treatment of larger tissue volumes to compensate for inaccuracies in targeting,” said lead author Louise Dickinson of UCL. “We are very pleased that the results of this pilot study demonstrate that deformable image registration is feasible and safe when introduced into a HIFU ablative therapy setting and suggests potential for improving the accuracy of targeting lesions using a tissue-preserving focal therapy approach.”

The research is based on breakthrough image analysis algorithms developed at the UCL Center for Medical Image Computing and has undergone extensive clinical assessment as part of clinical research studies led by Mark Emberton, MD, UCL professor of interventional oncology and director of the division of surgery and interventional science. Twenty-six prostate cancer patients have been effectively treated at the UCL Hospital (UCLH) using the Sonablate 500 with the aid of this software as part of the INDEX Trial.

Dr. Dickinson added, “Indeed, if on-going clinical trials demonstrate clinical utility for focal therapy as an alternative to current standards of care, it is possible that image registration software may be essential for the efficient implementation of truly focal therapy techniques in which individual tumors are treated within an appropriate and safe surgical margin. The use of MRI-US registration potentially provides a cost-effective solution that, as shown in this study, can be easily integrated within existing workflows and interfaces, using standard surgical equipment.”

The UCL group, led by Dr. Dean Barratt, is now developing a commercial version of their prostate image registration/fusion software, called SmartTarget. The project focuses on translating technology, which combines advanced diagnostic imaging with cutting-edge image guidance technology to provide clinicians with data on cancer size, location, and shape so that it can be used to direct and guide prostate biopsy and minimally invasive cancer treatments. Specifically, the SmartTarget system utilizes MRI technology, which can identify and differentiate clinically significant cancers in a large proportion of patients.

“The adoption of tissue-preserving approaches for the treatment of prostate cancer has been hampered by limitations in diagnosing and localizing clinically significant prostate cancers,” said Mark Carol, MD, chief development officer for SonaCare Medical. “The publication of these results in the British Journal of Urology International is a tremendous validation of UCL’s pioneering research in image registration and fusion technology that has led to significant advances in the validation and adoption of focal HIFU. We are proud to work with UCL to expand access to this breakthrough technology designed to enable targeted treatment of clinically significant prostate cancers.”

Related Links:
University College London
SonaCare Medical
University College London Business