Ultrasound Treatment Used to Protect the Kidneys

The findings suggest that this simple and noninvasive tool may be an effective safeguard for at-risk patients.

Acute kidney injury, an abrupt decline in kidney function, is an increasingly prevalent and potentially serious condition in hospitalized patients. Acute kidney injury can at times occur after major surgery because the kidneys can be deprived of normal blood flow during the procedure. Once the injury develops, patients have few established treatment possibilities in addition to supportive care.

Mark Okusa, MD, Joseph Gigliotti, PhD, from the University of Virginia (USA), and their colleagues discovered that a noninvasive, drug-free, ultrasound-based treatment could prevent acute kidney injury in mice. When they exposed anesthetized mice to ultrasound with a routine clinical imaging system 24 hours prior to blood disruption to the kidneys, the mice exhibited preserved kidney health after blood flow was restored. In contrast, sham-treated mice exhibited significant kidney injury. Further analyses revealed that the ultrasound treatment likely stimulated an anti-inflammatory response that originated from the spleen and was responsible for protecting the kidneys.

“Our studies using noninvasive ultrasound now provide us with an active treatment that appears to be simple, effective, and nontoxic for the prevention of acute kidney injury,” said Dr. Okusa. “To our knowledge this has never been described for the prevention of tissue or organ injury. Interestingly, we suspect that similar mechanisms that lead to kidney injury may also lead to lung, heart, and liver damage and that this form of therapy might be effective for prevention of injury in other organs as well.”

The study’s finding are slated to be published in an upcoming issue of the Journal of the American Society of Nephrology (JASN).In an accompanying editorial, Alain Le Moine, MD, PhD, from Erasme Hospital (Brussels, Belgium), and his colleagues noted that prospects that could result from the research are numerous and promising because many procedures that carry a very high risk of AKI are planned. “In searching for novel approaches to prevent and even cure AKI, we believe that splenic ultrasound stimulation has a bright future ahead,” they reported.

Related Links:
University of Virginia
Erasme Hospital