fMRI Identifies Asymptomatic Individuals at Risk for Stroke

Carotid artery stenosis is the primary cause of up to 20% of ischemic strokes, which result from an obstruction within a blood vessel and make up 85% of all strokes.

Stroke victims frequently undergo revascularization procedures such as carotid endarterectomy (surgical removal of the plaque) to restore blood flow, but use of the procedures in asymptomatic patients is more controversial, according to Ankur Pandya, PhD, assistant professor of healthcare policy and research and public health in radiology at Weill Cornell Medical College (New York, NY, USA). “There are complications and costs associated with these revascularization procedures, and they are often done without knowing if the risks and costs are worth the benefits,” Dr. Pandya said.

Dr. Pandya and colleagues recently evaluated the impact of cerebrovascular reserve (CVR) testing, a measure of blood flow reserve to the brain, on asymptomatic people with significant carotid artery stenosis. While different imaging modalities can be used in CVR testing, the researchers used transcranial Doppler (TCD) sonography, an inexpensive, widely available option that does not expose patients to ionizing radiation. They constructed a mathematical model that allowed them to make hypothetical comparisons among three diverse approaches: CVR testing, immediate revascularization with carotid endarterectomy, and medical therapy-based management with subsequent revascularization only for patients whose stenosis got worse.

The CVR-based strategy, which led to approximately 50% of the patients receiving revascularization, appeared to have the most favorable balance of benefits and costs. The medical therapy-based approach was associated with the lowest lifetime costs and the fewest revascularizations; however, it also resulted in the lowest life expectancy and lifetime quality-adjusted years, which account for both the quality and length of life experienced by patients. The immediate revascularization strategy had the highest costs, by a wide margin, and only incremental health benefits compared with the CVR-based approach.

“The study results show that imaging can be a cost-effective tool to stratify patients by risk of stroke and help sort patients into invasive, expensive interventions and less invasive options,” Dr. Pandya said.

Dr. Pandya reported that CVR testing also has the potential to help characterize whether carotid artery plaque is causing abnormal brain blood flow patterns which may, therefore, identify the patients who are at greatest risk of stroke. “CVR testing with ultrasound could be used to stratify patients by risk based on abnormal blood flow patterns to the brain, and then other imaging tests like MRI could be employed to look at the composition and stability of plaque, which may give greater insight into those plaques most likely to rupture and cause symptoms,” Dr. Pandya said.

Cost-effectiveness models such as the one used in the study have gained acceptance recently and are already used by healthcare payers in Canada, Europe, and Australia. Dr. Pandya expects these models to become more prominent in the United States as healthcare reform evolves. “Our model takes all these pieces of information on risks, costs and benefits and does the math in a systematic way to help clinicians make decisions,” he said.

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Weill Cornell Medical College