Human Prostate Cancer Study Evaluates New Imaging Biomarker

Existing imaging techniques are not sensitive or specific enough to detect these lesions. The results of the study show that the [18F]DCFPyL radiotracer was safe, and compared to the first generation radiotracer was able to parallel the expected uptake with much improved visual conspicuity of suspected lesions.

The [18F]DCFPyL biomarker is a PET agent that attaches to the Prostate-Specific Membrane Antigen (PSMA) and can subsequently be measured using a Positron Emission Tomography (PET) scan. The biomarker produced images that providing clearer images than the first generation agent and resulted in 50% less radiation dose in the most sensitive organs.

Dr. Jason Lewis, President of the World Molecular Imaging Society (WMIS) said, “The basis of more accurate, molecularly-informed classification of disease is the premise of precision medicine and specific molecular imaging biomarkers are the keys to determine how we classify diseases, how we select therapy, how we monitor therapy, and ultimately how we make treatments more accurate for each individual for better patient outcomes. We commend the team at Johns Hopkins for developing a more sensitive and accurate PSMA.”

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