3D Printing and CT Imaging Used to Guide Human Face Transplants

The study’s findings were presented at the annual meeting of the Radiological Society of North America (RSNA), held in Chicago, IL, USA; November 30 to December 5, 2014. Physicians from Brigham and Women’s Hospital (Boston, MA, USA) performed the first US full-face transplantation in 2011 and have subsequently completed four additional face transplants. The procedure is performed on patients who have lost some or all of their face as a result of disease or injury.

In the study, researchers led by Frank J. Rybicki, MD, radiologist and director of the hospital’s Applied Imaging Science Laboratory, Bohdan Pomahac, MD, lead face transplantation surgeon, and Amir Imanzadeh, MD, research fellow, assessed the clinical impact of using 3-D printed models of the recipient’s head in the planning of face transplantation surgery. “This is a complex surgery and its success is dependent on surgical planning,” Dr. Rybicki said. “Our study demonstrated that if you use this model and hold the skull in your hand, there is no better way to plan the procedure.”

Each of the transplant patients underwent preoperative CT scanning with 3-D visualization. To build each life-size skull model, the CT images of the transplant recipient’s head were segmented and processed using specialized software, creating customized data files that were input into a 3-D printer. “In some patients, we need to modify the recipient’s facial bones prior to transplantation,” Dr. Imanzadeh said. “The 3-D printed model helps us to prepare the facial structures so when the actual transplantation occurs, the surgery goes more smoothly.”

Although the entire transplant procedure lasts as long as 25 hours, the actual vascular connections from the donor face to the recipient typically takes approximately one hour, during which time the patient’s blood flow must be stopped. “If there are absent or missing bony structures needed for reconstruction, we can make modifications based on the 3-D printed model prior to the actual transplantation, instead of taking the time to do alterations during ischemia time,” Dr. Rybicki said. “The 3-D model is important for making the transplant cosmetically appealing.”

Moreover, the researchers reported they employed the models in the operating room to optimize the surgeons’ understanding of the anatomy of the recipient’s face during the procedure. “You can spin, rotate and scroll through as many CT images as you want but there’s no substitute for having the real thing in your hand,” Dr. Rybicki said. “The ability to work with the model gives you an unprecedented level of reassurance and confidence in the procedure.”

Senior surgeons and radiologists involved in the five face transplantations agreed that the 3-D printed models provided superior preoperative data and allowed complex anatomy and bony defects to be better appreciated, reducing total procedure time. “Less time spent in the operating room is better for overall patient outcomes,” Dr. Pomahac added.

Based on the results of this study, 3-D printing is now regularly used for surgical planning for face transplantation procedures at Brigham and Women’s Hospital, and 3-D printed models may be implemented in other complicated surgeries.

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