Perfusion Regulators Increase Circulation During Emergencies

The ResQPOD and ResQGARD impedance threshold devices (ITDs) deliver POD therapy to increase circulation, protecting the heart, brain, and other vital organs when blood flow is compromised. The ResQPOD works by regulating pressures in the thorax during states of hypotension by preventing unnecessary air from entering the chest during cardiopulmonary resuscitation (CPR). As the chest wall recoils, the vacuum in the thorax is greater; this enhanced vacuum pulls more blood back to the heart, doubling blood flow and systolic blood pressure (BP). This increases cardiac output and blood flow to the brain by 50%, without restricting patient ventilation and exhalation.

The ResQGARD increases BP during hypotension from a variety of causes, such as orthostatic intolerance, hypovolemia, heat shock, dialysis, and blood donation. During inspiration, a negative pressure created from expansion of the thorax draws air into the lungs. When inspiratory impedance is applied to the breathing circuit, it enhances the vacuum in the chest, which pulls more blood back to the heart, resulting in increased preload, thus enhancing cardiac output on the subsequent cardiac contraction. The core component of the device is an atmospheric pressure sensing valve that creates the correct amount of therapeutic resistance during inspiration.

In principle, the ResQGARD uses similar technology as the ResQPOD, but is designed for patients who are breathing spontaneously. This is reflected in the valve mechanism itself, the valve cracking pressure, and a supplemental O2 port in the ResQGARD. The ResQPOD and ResQGARD are products of Advanced Circulatory (Roseville, MN, USA), and can be used on a facemask or with a mouthpiece.

“Our Perfusion on Demand therapy has the potential to have a global impact on patient care, and this financing round will help us push education and adoption of our life-saving therapies,” said Mike Black, CEO of Advanced Circulatory.

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