We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

First-Of-Its-Kind Technology Enables Replacement of Diseased Heart Valve without Surgery

By HospiMedica International staff writers
Posted on 06 Feb 2023
Print article
Image: The innovative RoseDoc platform replaces the patient\'s leaky heart valve (Photo courtesy of TruLeaf Medical)
Image: The innovative RoseDoc platform replaces the patient\'s leaky heart valve (Photo courtesy of TruLeaf Medical)

Globally, there are tens of millions of patients with severe, life-threatening mitral valve regurgitation (leaky valve) that causes heart failure, heart arrhythmia and brain strokes, resulting in high mortality. Approximately 10% of the global population aged over 75 years suffers from leaky mitral heart valve. Such patients experience a significant reduction in their functional capacity which manifests as fatigue, shortness of breath upon exertion with lower and lower exertion and arrhythmias, thus gradually affecting their daily routine. Patients with leaky mitral valve have a substantially shorter life expectancy than age and gender-matched people. Currently, complex open-heart surgery to repair or replace the leaky heart valve is the most effective treatment for such patients but is offered to just 2% of patients due to a high surgical risk. Now, a unique platform offers a first-of-its-kind technology for allowing implantation of a biological bioprosthesis to replace the diseased valve through catheterization only.

The unique RoseDoc platform developed by TruLeaf Medical (Or Akiva, Israel) enables a ground-breaking procedure that is minimally invasive, performed on a beating heart via two needle punctures without surgery or the use of a heart-lung machine. The procedure is associated with significantly lower risk than traditional open-heart mitral valve surgery. This means that millions of patients across the world, who until now were considered to be inoperable, can receive a new valve and look forward to a substantial improvement in their functional capacity, quality of life and life expectancy.

TruLeaf has received the Helsinki Ethics Committee's approval to conduct clinical trial of its innovative platform in humans. As part of the trial, a prosthetic mitral valve will be implanted via two needle sticks in the groins in a two-stage catheterization procedure without the need for open-heart surgery (transcatheter mitral valve replacement, TMVR). The implantation of the RoseDoc, which replaces the patient's leaky heart valve, will be done in two stages. In the first stage, a docking station will be implanted in the left atrium, followed by implantation of an artificial 'biological' mitral valve prosthesis after a few weeks. The approval to carry out implantation of TruLeaf's TMVR platform in humans comes a few months after completing the R&D of all the components of the platform, as well as a series of successful short-term and long-term animal experiments.

"The main challenge with existing TMVR technologies is achieving optimal anchoring of the valve prosthesis to the heart, given the complex native mitral valve anatomy and physiology,” explained Benjamin Spencer, TruLeaf Medical CEO. “The RoseDoc TMVR platform is technically simple, safe and has been proven to be effective in rigorous long-term animal testing. Complete elimination of the leak prevents progressive dilation of the heart, which, by itself, in a vicious cycle, worsens the leak, leading to a progressive weakening of the heart muscle and intractable heart failure. At present, patients with severe mitral valve leak refractory to maximal medical treatment remain without an effective treatment. The vast majority of these patients are declined surgery due to prohibitive risk. The RoseDoc unique TMVR platform literally gives these patients new hope.”

Related Links:
TruLeaf Medical

Platinum Supplier
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Portable Suction Device
330 Multifunction Aspirator
Digital Radiography System
Moviplan iC DR
ICU Medical Ceiling Supply Unit

Print article



view channel
Image: The WHO has conditionally recommended the use of algorithms in assisting with pediatric tuberculosis diagnosis (Photo courtesy of Pexels)

New Evidence-Based Algorithms Could Improve Diagnosis of Pediatric Tuberculosis

Tuberculosis (TB) continues to be one of the most prevalent causes of death among younger populations worldwide. Research indicates that over 96% of the deadly TB cases in children under the age of 15... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more


view channel
Image: The demand for endometrial ablation devices is increasing due to rising prevalence of gynecological disorders (Photo courtesy of Pexels)

Global Endometrial Ablation Market Driven by Rising Prevalence of Gynecological Disorders

Gynecological disorders, such as menorrhagia, PCOD, abnormal vaginal bleeding, affect millions of women globally every year and are on the rise. Abnormal Uterine Bleeding (AUB) is the most common disorder... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.