We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Novel SMP Responds Directly to Enzymatic Activity

By HospiMedica International staff writers
Posted on 14 Mar 2019
Print article
Image: A shape memory polymer (SMP) that responds to enzymes could promote healing (Photo courtesy of Syracuse University).
Image: A shape memory polymer (SMP) that responds to enzymes could promote healing (Photo courtesy of Syracuse University).
A new study shows how a novel shape memory polymer (SMP) that responds to exposure to enzymes could soon be used to treat open wounds, infections, and cancer.

Developed by researchers at Syracuse University (NY, USA) and Bucknell University (Lewisburg, PA, USA), the new SMP includes a shape fixing component, poly(ε-caprolactone) (PCL), that is vulnerable to enzymatic degradation, and a shape memory component, Pellethane, that is enzymatically stable. As the shape fixing PCL component undergoes enzymatically-catalyzed degradation, the SMP can return to its original, programmed shape. It requires no additional trigger, such as a change in temperature, and could thus respond to cellular activity.

The researchers also analyzed material properties, shape memory performance, and cytocompatibility of the enzymatically-catalyzed shape memory response. The results demonstrate enzymatic recovery, as contraction of tensile specimens, and that shape recovery is achieved by degradation of the PCL shape-fixing phase. In addition, both the materials composing the SMP and the process of enzymatic shape recovery were cytocompatible. The study describing the SMP was published on January 15, 2019, in Acta Biomaterialia.

“We anticipate that the materials we're developing could have broad application in health care. For example, our SMPs could be used in drugs that only activate when the target cells or organ are in the desired physiological state, in scaffolds that guide tissue regeneration in response to the behavior of the regenerating tissue itself, and in decision-making biosensors that guide patient treatment more effectively,” said senior author Professor James Henderson, PhD, of Syracuse University. “We're very excited to have achieved these first enzymatically responsive SMPs.”

“The enzymatic sensitivity of the material allows it to respond directly to cell behavior. For instance, you could place it over a wound, and as the tissue remodeled and degraded it, the SMP would slowly pull the wound closed,” said lead author candidate Shelby Buffington, MSc, a biomedical engineering PhD candidate at Syracuse University. “It could be adapted to play a role in treating infections and cancer by adjusting the material's chemistry.”

SMPs include foams, scaffolds, meshes, and other polymeric substrates that have the ability to return from a deformed state (temporary shape) to their original (permanent) shape induced by an external stimulus, such as a temperature change, an electric or magnetic field, light, or a chemical solution. As well as polymers in general, SMPs also cover a wide property-range from stable to biodegradable, from soft to hard, and from elastic to rigid, depending on the structural units that constitute the SMP.

Related Links:
Syracuse University
Bucknell University

Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Gold Member
12-Channel ECG
CM1200B
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
DR Flat Panel Detector
1500L

Print article

Channels

Surgical Techniques

view channel
Image: New studies have highlighted the benefits of robotic-assisted joint replacement surgery (Photo courtesy of HSS)

Robotic-Assisted Joint Replacement Surgery Improves Patient Outcomes

Robotics is being increasingly integrated into joint replacement surgeries, although more research is required to understand its benefits. Now, researchers from Hospital for Special Surgery (HSS, New York,... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The new eye-safe laser technology can diagnose traumatic brain injury (Photo courtesy of 123RF)

Novel Diagnostic Hand-Held Device Detects Known Biomarkers for Traumatic Brain Injury

The growing need for prompt and efficient diagnosis of traumatic brain injury (TBI), a major cause of mortality globally, has spurred the development of innovative diagnostic technologies.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.