We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App




New AACC Procalcitonin Testing Guidance to Improve Care for Patients with Bacterial Infections

By HospiMedica International staff writers
Posted on 08 May 2023
Print article
Illustration
Illustration

Although procalcitonin tests have been employed in Europe for years, they were only introduced in the U.S. in 2017 when the FDA approved their use for guiding antibiotic treatment and predicting the likelihood of death within 28 days for sepsis patients. Given their recent arrival in the U.S., there remains uncertainty about the appropriate use of these tests, which are sometimes ordered in clinically inapplicable situations. To address this issue, new guidance offers a comprehensive analysis of procalcitonin research and its limitations, aiming to improve testing and treatment practices.

The American Association for Clinical Chemistry (AACC, Washington, DC, USA) has released expert guidance on procalcitonin testing, a blood marker used to detect severe bacterial infections and sepsis. This guidance aims to provide clarity for clinicians and laboratory professionals, enhancing the treatment of critically ill patients and those with specific lower respiratory infections. The document tackles key questions related to procalcitonin usage in managing adult, pediatric, and newborn patients with suspected sepsis and/or bacterial infections, especially those affecting the lower respiratory tract. It also examines the evidence for using these tests to inform antimicrobial treatment decisions and predict patient outcomes.

There is strong evidence supporting procalcitonin testing in guiding clinicians on when to discontinue antibiotic treatment in critically ill patients and those with certain lower respiratory tract infections. The AACC guidance suggests incorporating procalcitonin testing into comprehensive antimicrobial stewardship efforts, involving multidisciplinary teams. Some studies indicate that procalcitonin levels can also help determine when to stop antibiotics in newborns and pediatric patients with suspected sepsis who exhibit clinical improvement. However, the guidance authors believe these studies are insufficient in size to establish standard levels applicable across pediatric populations, given that procalcitonin reference intervals were established for adults. Consequently, if procalcitonin testing is used for these groups, it is important to define pediatric reference intervals or interpretive criteria.

Despite the FDA's approval of procalcitonin tests for predicting 28-day mortality risk in sepsis patients, the guidance does not recommend their routine use for this purpose. This is due to inconsistent procalcitonin cut-offs and clearance parameters, as well as a lack of substantial evidence demonstrating the benefit of estimating 28-day mortality risk for patients with sepsis and lower respiratory tract infections.

"Improved outcomes from [procalcitonin] implementation are more likely to be realized when the test is used in conjunction with antimicrobial stewardship programs, institutional interpretive algorithms, and clinical decision support tools," said the guidance document authors Drs. Allison B. Chambliss, Khushbu Patel, Jessica M. Colón-Franco, Joshua Hayden, Sophie E. Katz, Emi Minejima, and Alison Woodworth. "Successful implementation of clinical [procalcitonin] requires a multidisciplinary effort among laboratorians, pharmacists, and infectious disease providers."

 

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Traumatic Brain Injury Whole Blood Test
i-STAT TBI CARTRIDGE

Print article

Channels

Surgical Techniques

view channel
Image: Concept of the wirelessly actuated undulating pump and its integration into an esophageal stent (Photo courtesy of Advanced Functional Materials/ doi.org/10.1002/adfm.202405865)

Wirelessly Activated Robotic Device Aids Digestion in Patients with Compromised Organs

The transport of fluids and solids is essential in the human body, driven by a wave-like movement in the lumen known as peristalsis. However, peristalsis can be disrupted in patients who have obstructions... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: POCT offers cost-effective, accessible, and immediate diagnostic solutions (Photo courtesy of Flinders University)

POCT for Infectious Diseases Delivers Laboratory Equivalent Pathology Results

On-site pathology tests for infectious diseases in rural and remote locations can achieve the same level of reliability and accuracy as those conducted in hospital laboratories, a recent study suggests.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.