We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Ingestible Intestinal Capsule Non-Invasively Analyzes Bacteria and Viruses in Digestive System

By HospiMedica International staff writers
Posted on 12 May 2023
Print article
Image: The non-invasive, ingestible intestinal sampling device sheds light on human gut activities (Photo courtesy of Envivo Bio)
Image: The non-invasive, ingestible intestinal sampling device sheds light on human gut activities (Photo courtesy of Envivo Bio)

Increasing evidence suggests that the gut microbiome and metabolome play a crucial role in various diseases, as well as in the digestion of food, immune system regulation, and protection against pathogens, all of which have significant implications for human health and disease. Given the regional heterogeneity of the intestinal tract, conventional sampling methods such as endoscopic biopsies and stool collection provide limited insight into how intestinal microbes and metabolites influence human physiology. Now, an innovative intestinal sampling device can non-invasively and accurately profile the human gut microbiome and metabolome under physiological conditions for the first time.

A landmark study by a group of researchers suggests that Envivo Bio Inc.’s (San Francisco, CA, USA) CapScan, the only device of its kind, has the potential to expedite microbiome-related research and biopharmaceutical drug discovery and development initiatives. CapScan is a non-invasive, ingestible collection device approximately the size of a vitamin pill. Each device is equipped with a pH-targeted enteric coating, designed to dissolve at a pre-determined rate based on the unique pH levels of the various regions of the human intestines. Once this coating dissolves, CapScan's internal bladder opens and draws in luminal content, which is then analyzed externally.

In the study, the researchers used CapScan to gather 240 intestinal samples from 15 healthy participants. Each participant swallowed sets of four devices, each designed to open at progressively higher pH levels. After the devices were expelled, the researchers employed multi-omics to examine the vast sets of microbiome, metabolome, and proteome data collected regionally throughout the gastrointestinal tract. The researchers found notable differences, for example, between bile acids in the small intestine and stool samples, which could be scientifically and clinically significant. Moreover, an accompanying study demonstrated the potential for further spatiotemporal profiling of the gut metabolome using CapScan, including differences in dietary and lipid compounds. Collectively, the results from both studies establish the feasibility and usefulness of CapScan for the collection, characterization, and quantification of intestinal microbiota, metabolome, host proteins, and bile acids along the human intestine in a safe and routine manner.

“Measuring gut metabolites in stool is like studying an elephant by examining its tail,” said Dari Shalon, Ph.D., founder and CEO of Envivo Bio. “Most metabolites are made, transformed and utilized higher up in the intestines and don’t even make it into the stool. CapScan gives us a fuller picture of the gut metabolome and its interactions with the gut microbiome for the first time.”

“Our research confirms that, up until now, studies of the gut microbiome have really been studies of the stool microbiome, which missed out on most of the biological activity in our intestinal tract,” added Shalon. “By enabling researchers to sample and assess each of the diverse intestinal ecosystems separately and directly for the first time, CapScan opens the door to a new era of microbiome research.”

Related Links:
Envivo Bio Inc. 

Platinum Supplier
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Supplier
12-Channel ECG
Afterloader For Brachytherapy
X-Ray Generator
RF Series

Print article


Surgical Techniques

view channel
Image: Suppressing production of an immune protein could reduce rejection of biomedical implants (Photo courtesy of 123RF)

Protein Identified for Immune Rejection of Biomedical Implants to Pave Way for Bio-Integrative Medical Devices

Biomedical implants like breast implants, pacemakers, and orthopedic devices have revolutionized healthcare, yet a substantial number of these implants face rejection by the body and have to be removed.... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The broad-spectrum POC coagulometer is well-suited for emergency room and emergency vehicle use (Photo courtesy of Perosphere)

Novel POC Coagulometer with Lab-Like Precision to Revolutionize Coagulation Testing

In emergency settings, when patients arrive with a bleed or require urgent surgery, doctors rely solely on clinical judgment to determine if a patient is adequately anticoagulated for reversal treatment.... Read more


view channel
Image: The global surgical lights market is expected to grow by close to USD 0.50 billion from 2022 to 2027 (Photo courtesy of Freepik)

Global Surgical Lights Market Driven by Increasing Number of Procedures

The global surgical lights market is set to witness high growth, largely due to the increasing incidence of chronic illnesses, a surge in demand for cosmetic and plastic surgeries, and untapped opportunities... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.