Surgical Gel Used to Stop Bleeding May Confuse Mammograms

She saw a suspicious pattern of white specks, much like grains of salt. The specks were calcium deposits similar to microcalcifications that sometimes are a sign of early breast cancer. But it was too early for the patient's breast cancer to have returned because it had been only one month since her lumpectomy. It turns out the microcalcifications were not from cancer; instead, they were due to a gel that is sometimes used during surgery to stop bleeding.

Dr. Kathleen Ward and colleagues from Loyola University Health System (Chicago, UL, USA) reported seven cases in which the sealant mimicked malignant microcalcifications in mammograms. The sealant, FloSeal, "is not recommended for use on breast tissue," Dr. Ward and colleagues reported. Dr. Ward is medical director of Women's Health Imaging and an assistant professor in the department of radiology at Loyola University Chicago Stritch School of Medicine.

FloSeal is among the products surgeons use to stop bleeding when sutures or staples are not sufficient or are impractical. FloSeal typically stops bleeding in two minutes or less. "We hope our study will raise awareness for others who may be using this product or any similar product," said first author Dr. Amy Henkel, a third-year radiology resident at Loyola.

Previous studies have described the use of FloSeal in urologic surgery, such as kidney resection, and cardiovascular surgery. FloSeal does not cause imaging problems for those procedures, but should not be used in breast surgery; according to study coauthor Dr. Richard Cooper, a professor in the department of radiology at Stritch. The sealant was developed by Baxter (Deerfield, IL, USA).

The study was published in the November 2008 issue of the American Journal of Roentgenology (AJR). In six patients, the microcalcifications caused by FloSeal were seen on six-month follow-up mammograms. In the seventh patient, these microcalcifications were seen on a mammogram taken one month after lumpectomy to look for residual malignant calcifications.

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