We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App

One-Hour Endoscopic Procedure Could Eliminate Need for Insulin for Type 2 Diabetes

By HospiMedica International staff writers
Posted on 14 May 2024
Print article
Image: The potential for controlling diabetes with a single endoscopic treatment is spectacular (Photo courtesy of 123RF)
Image: The potential for controlling diabetes with a single endoscopic treatment is spectacular (Photo courtesy of 123RF)

Over 37 million Americans are diagnosed with diabetes, and more than 90% of these cases are Type 2 diabetes. This form of diabetes is most commonly seen in individuals over 45, though an increasing number of children, teenagers, and young adults are being diagnosed. Managing glucose can be costly with medications, and using insulin injections comes with side effects such as the risk of low blood sugar and weight gain. Now, an innovative procedure that involves the use of controlled electrical pulses to alter the lining of the first part of the small intestine could enable patients with Type 2 diabetes to discontinue insulin use while maintaining control of their blood glucose levels.

Previous research had studied the effects of ablating the small intestine's lining with heat, particularly after noting that patients undergoing gastric bypass surgery showed immediate improvements in insulin regulation post-operation, prior to any weight loss. This observation led researchers to propose that bypassing a specific part of the small intestine contributes to blood sugar management in Type 2 diabetes. It is theorized that prolonged exposure to a diet high in sugar and calories triggers an unidentified change in this intestinal segment, which in turn causes resistance to the body's insulin. Rejuvenating this intestinal tissue may enhance the body's responsiveness to its insulin, especially in Type 2 diabetes patients who still produce insulin naturally.

In a pioneering study conducted at the Amsterdam University Medical Center (Amsterdam, the Netherlands), 14 patients were treated with an endoscopic procedure that applied alternating electrical pulses to the duodenum—the section of the small intestine just below the stomach. This procedure lasted about an hour, after which patients were released the same day. They then followed a calorie-controlled liquid diet for two weeks. Subsequently, these patients started on semaglutide, a diabetes medication, gradually increasing the dose to 1 mg per week. While semaglutide alone typically enables roughly 20% of Type 2 diabetes patients to stop using insulin, in this study, 12 out of 14 patients, or 86%, successfully maintained optimal glycemic control without insulin for an entire year. This suggests that the improvements could be attributed to the new procedure rather than solely to the medication. Researchers are now initiating a double-blind randomized controlled trial to further investigate these findings.

“The potential for controlling diabetes with a single endoscopic treatment is spectacular,” said Celine Busch, the study’s lead researcher and PhD candidate in gastroenterology at Amsterdam University Medical Center. “One of the biggest advantages of this treatment is that a single outpatient endoscopic procedure provides glycemic control, a potential improvement over drug treatment, which depends on patients taking their medication day in, day out.”

Related Links:
Amsterdam UMC

Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Gold Member
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Silver Member
Wireless Mobile ECG Recorder
Pre-Op Planning Solution
Sectra 3D Trauma

Print article


Surgical Techniques

view channel
Image: The multi-sensing device can be implanted into blood vessels to help physicians deliver timely treatment (Photo courtesy of IIT)

Miniaturized Implantable Multi-Sensors Device to Monitor Vessels Health

Researchers have embarked on a project to develop a multi-sensing device that can be implanted into blood vessels like peripheral veins or arteries to monitor a range of bodily parameters and overall health status.... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.