We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
16 Feb 2023 - 18 Feb 2023

Cardiac Plug Lowers Risk of Stroke in Atrial Fibrillation

By HospiMedica International staff writers
Posted on 28 Oct 2015
Print article
The Amplatzer Cardiac Plug
The Amplatzer Cardiac Plug (Photo courtesy of St Jude medical)
Left atrial appendage occlusion (LAAO) reduces the risk of subsequent strokes in patients with previous brain hemorrhages and diagnosed atrial fibrillation (AF), according to a new study.

Researchers at AHEPA University Hospital Thessaloniki (AHEPA; Greece) reported post-aurgical results on 1,001 patients treated from December 2008 to November 2013 at 22 institutions; about 57% of the patients had permanent AF and the others had persistent or paroxysmal AF. Among the patients, 19% had experienced previous intracranial bleeding, 47% had experienced previous major bleeding episodes, and 14% had experienced gastrointestinal bleeding. In all, 35% of the patients were considered at high-risk for bleeding, and were eligible for a LLAO closure device.

The eligible patients received the Amplatzer Cardiac Plug (ACP), a self-expanding, braided Nitinol mesh that works by blocking the LAA at its opening, minimizing the opportunity for blood clots to form or migrate into the bloodstream. The device, a product of St. Jude Medical (SJM; St. Paul, MN, USA), is offered in eight sizes to accommodate varying anatomies, and is preloaded into the delivery catheter, which simplifies device preparation and ultimately streamlines the entire procedure for the physician.

The results showed that when compared with the expected annual stroke risk of 5.62% a year, patients who underwent an ACP implant had a stroke risk of 2.30%, a decrease of 59%. Bleeding reduction decreased from an expected annual rate of 5.34% to an actual rate of 2.08%, for a 61% reduction. Major bleeding in patients with previous intracranial hemorrhage who underwent the ACP procedure was 0.7%, versus an estimated bleeding rate of 6.4%, an 89% reduction. The study was presented at the Transcatheter Cardiovascular Therapeutics (TCT) annual meeting, held during October 2015 in San Francisco (CA, USA).

“Compared with historical risks, patients had a 75% reduction of stroke or transient ischemic attacks and a remarkably low frequency of major bleeding at 0.7% when they had appendage closure with the Amplatzer Cardiac Plug,” concluded lead author and study presenter Apostolos Tzikas, MD, PhD, of AHEPA, and colleagues. “Further studies are required to confirm these initial positive results from the ACP Registry.”

The LAA is a tube-shaped appendage connected to the left atrium that can potentially hold static blood during an episode of AF, increasing the likelihood of clot formation; research shows that in AF patients, approximately 90% of all cardiac blood clots form in the LAA. If a clot forms in the LAA and is then released into the heart, it may enter blood circulation, travel to the brain, block a vessel and cause an ischemic stroke.

Related Links:

AHEPA University Hospital Thessaloniki
St. Jude Medical

Gold Supplier
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Mobile Radiography System
NeuVision 550M (Plus)
Portable Manual Defibrillator
Portable Finger Pulse Oximeter
Onyx Vantage 9590
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to HospiMedica.com and get complete access to news and events that shape the world of Hospital Medicine.
  • Free digital version edition of HospiMedica International sent by email on regular basis
  • Free print version of HospiMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of HospiMedica International in digital format
  • Free HospiMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
Click here to Register



view channel
Image: MyoVista Wavelet technology utilizes AI for early detection of heart disease (Photo courtesy of Heart Test Laboratories)

Novel ECG Technology Utilizes AI for Early Detection of Heart Disease

Cardiovascular disease is responsible for 17.9 million deaths every year, or about 32% of all deaths worldwide. Every week, millions of electrocardiographs (ECGs) are performed across the world, making... Read more

Critical Care

view channel
Image: Studies have shown the Autus Valve maintains control of blood flow as it expands (Photo courtesy of Boston Children’s Hospital)

Heart Valve That Grows Along With Child Could Reduce Invasive Surgeries

In children with congenital pulmonary valve disease, the flow of blood between the heart and lungs is impeded. In cases where the pulmonary valves have narrowed or are leaking and cannot be treated effectively... Read more

Health IT

view channel
Image: Using digital data can improve health outcomes (Photo courtesy of Unsplash)

Electronic Health Records May Be Key to Improving Patient Care, Study Finds

When a patient gets transferred from a hospital to a nearby specialist or rehabilitation facility, it is often difficult for personnel at the new facility to access the patient’s electronic health records... Read more

Point of Care

view channel
Image: Steripath improves the diagnostic accuracy and timeliness of sepsis test results (Photo courtesy of Magnolia)

All-in-One Device Reduces False-Positive Diagnostic Test Results for Bloodstream Infections

Blood cultures are considered the gold standard diagnostic test for the detection of blood stream infections, such as sepsis. However, positive blood culture results can be frequently wrong, and about... Read more


view channel
Image: The global patient positioning systems market is projected to reach USD 1.7 billion by 2027 (Photo courtesy of Pexels)

Global Patient Positioning Systems Market Driven by Increasing Chronic Diseases

The global patient positioning systems market is projected to grow at a CAGR of 4% from USD 1.4 billion in 2022 to USD 1.7 billion by 2027, driven by increasing technological advancements in medical devices,... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.