We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Ampronix,  Inc

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
29 Aug 2020 - 02 Sep 2020
Virtual Venue

Cardiac Plug Lowers Risk of Stroke in Atrial Fibrillation

By HospiMedica International staff writers
Posted on 28 Oct 2015
Print article
The Amplatzer Cardiac Plug
The Amplatzer Cardiac Plug (Photo courtesy of St Jude medical)
Left atrial appendage occlusion (LAAO) reduces the risk of subsequent strokes in patients with previous brain hemorrhages and diagnosed atrial fibrillation (AF), according to a new study.

Researchers at AHEPA University Hospital Thessaloniki (AHEPA; Greece) reported post-aurgical results on 1,001 patients treated from December 2008 to November 2013 at 22 institutions; about 57% of the patients had permanent AF and the others had persistent or paroxysmal AF. Among the patients, 19% had experienced previous intracranial bleeding, 47% had experienced previous major bleeding episodes, and 14% had experienced gastrointestinal bleeding. In all, 35% of the patients were considered at high-risk for bleeding, and were eligible for a LLAO closure device.

The eligible patients received the Amplatzer Cardiac Plug (ACP), a self-expanding, braided Nitinol mesh that works by blocking the LAA at its opening, minimizing the opportunity for blood clots to form or migrate into the bloodstream. The device, a product of St. Jude Medical (SJM; St. Paul, MN, USA), is offered in eight sizes to accommodate varying anatomies, and is preloaded into the delivery catheter, which simplifies device preparation and ultimately streamlines the entire procedure for the physician.

The results showed that when compared with the expected annual stroke risk of 5.62% a year, patients who underwent an ACP implant had a stroke risk of 2.30%, a decrease of 59%. Bleeding reduction decreased from an expected annual rate of 5.34% to an actual rate of 2.08%, for a 61% reduction. Major bleeding in patients with previous intracranial hemorrhage who underwent the ACP procedure was 0.7%, versus an estimated bleeding rate of 6.4%, an 89% reduction. The study was presented at the Transcatheter Cardiovascular Therapeutics (TCT) annual meeting, held during October 2015 in San Francisco (CA, USA).

“Compared with historical risks, patients had a 75% reduction of stroke or transient ischemic attacks and a remarkably low frequency of major bleeding at 0.7% when they had appendage closure with the Amplatzer Cardiac Plug,” concluded lead author and study presenter Apostolos Tzikas, MD, PhD, of AHEPA, and colleagues. “Further studies are required to confirm these initial positive results from the ACP Registry.”

The LAA is a tube-shaped appendage connected to the left atrium that can potentially hold static blood during an episode of AF, increasing the likelihood of clot formation; research shows that in AF patients, approximately 90% of all cardiac blood clots form in the LAA. If a clot forms in the LAA and is then released into the heart, it may enter blood circulation, travel to the brain, block a vessel and cause an ischemic stroke.

Related Links:

AHEPA University Hospital Thessaloniki
St. Jude Medical

Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to HospiMedica.com and get complete access to news and events that shape the world of Hospital Medicine.
  • Free digital version edition of HospiMedica International sent by email on regular basis
  • Free print version of HospiMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of HospiMedica International in digital format
  • Free HospiMedica International Newsletter sent every 2 weeks containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
Click here to Register



view channel

Siemens to Acquire Varian Medical to Create Comprehensive Cancer Portfolio

Siemens Healthineers (Erlangen, Germany) has entered into an agreement to acquire Varian Medical Systems, Inc. (Palo Alto, CA, USA) that will lead to the creation of a global leader in healthcare with... Read more
Copyright © 2000-2020 Globetech Media. All rights reserved.