We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Endobronchial Valves Improve Lung Function in Emphysema

By HospiMedica International staff writers
Posted on 11 Jun 2018
Print article
Image: The Zephyr endobronchial valve (Photo courtesy of PulmonX).
Image: The Zephyr endobronchial valve (Photo courtesy of PulmonX).
An endobronchial valve (EBV) improves lung function, exercise capacity and quality of life in patients with heterogeneous emphysema and hyperinflation, according to a new study.

Researchers at Temple University (Philadelphia, PA, USA), University Medical Center Groningen (UMCG, The Netherlands), and other institutions conducted a study in 190 patients with severe heterogeneous emphysema and little to no collateral ventilation to evaluate the effectiveness and safety of the PulmonX (Redwood City, CA, USA) Zephyr EBV as compared to standard medical management of hyperinflation related to emphysema, which includes lung-volume-reduction surgery (LVRS), bullectomy, and lung transplantation.

In all, 128 patients were randomized to EBV, with a median of four valves placed, mostly in the left upper lung lobe. At 12-month follow-up, hyperinflation was reduced to a significantly greater extent in the EBV group, with 47.7% of EBV patients presenting a 15% or higher increase in post-bronchodilator forced expiratory volume (FEV1), versus 16.8% of those under standard medical care. They also had significant improvement in six-minute walk distance (6MWD) and respiratory questionnaire scores. The study was published on May 22, 2018, in the American Journal of Respiratory and Critical Care Medicine.

“Zephyr Valves offer clinically meaningful improvements in three important areas for patients - the ability to breathe better, be more active, and enjoy an improved quality of life,” said lead author Professor Gerard Criner, MD, of Temple University. “All primary and secondary endpoints were met, with Zephyr Valve treatment showing significant improvement for patients across multiple measures of breathing and quality of life. The Zephyr Valve also demonstrated an acceptable safety profile given the magnitude of benefit seen in this study.”

The Zephyr EBV is a one-way valve that blocks airflow to diseased regions of the lung, allowing healthy regions to expand and function more efficiently. The valves, which are either 4 or 5.5 millimeters in size, are implanted in a minimally invasive procedure using a bronchoscope equipped with a video camera. During the 60-minute procedure, 3-5 Zephyr valves are placed in airways leading to the diseased region of the lung. Once deployed, the self-expanding, one-way valve conforms to the bronchial wall and forms an airtight seal, blocking airflow to the diseased regions.

Related Links:
Temple University
University Medical Center Groningen

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
Disposable Protective Suit For Medical Use
Disposable Protective Suit For Medical Use
Silver Member
Compact 14-Day Uninterrupted Holter ECG
Medical Trolley
ASPEL WB-5 v.002

Print article


Critical Care

view channel
Image: Vascular flow modeling exemplar; intracranial aneurysm flow, treatment and thrombosis (Photo courtesy of University of Leeds)

Faster, More Accurate Blood Flow Simulation to Revolutionize Treatment of Vascular Diseases

The field of vascular flow modeling is vital for understanding and treating vascular diseases, but traditionally, these methods require extensive labor and computation. Now, researchers have made groundbreaking... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The new eye-safe laser technology can diagnose traumatic brain injury (Photo courtesy of 123RF)

Novel Diagnostic Hand-Held Device Detects Known Biomarkers for Traumatic Brain Injury

The growing need for prompt and efficient diagnosis of traumatic brain injury (TBI), a major cause of mortality globally, has spurred the development of innovative diagnostic technologies.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.