We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
ARAB HEALTH - INFORMA

Download Mobile App




Endobronchial Valves Improve Lung Function in Emphysema

By HospiMedica International staff writers
Posted on 11 Jun 2018
Print article
Image: The Zephyr endobronchial valve (Photo courtesy of PulmonX).
Image: The Zephyr endobronchial valve (Photo courtesy of PulmonX).
An endobronchial valve (EBV) improves lung function, exercise capacity and quality of life in patients with heterogeneous emphysema and hyperinflation, according to a new study.

Researchers at Temple University (Philadelphia, PA, USA), University Medical Center Groningen (UMCG, The Netherlands), and other institutions conducted a study in 190 patients with severe heterogeneous emphysema and little to no collateral ventilation to evaluate the effectiveness and safety of the PulmonX (Redwood City, CA, USA) Zephyr EBV as compared to standard medical management of hyperinflation related to emphysema, which includes lung-volume-reduction surgery (LVRS), bullectomy, and lung transplantation.

In all, 128 patients were randomized to EBV, with a median of four valves placed, mostly in the left upper lung lobe. At 12-month follow-up, hyperinflation was reduced to a significantly greater extent in the EBV group, with 47.7% of EBV patients presenting a 15% or higher increase in post-bronchodilator forced expiratory volume (FEV1), versus 16.8% of those under standard medical care. They also had significant improvement in six-minute walk distance (6MWD) and respiratory questionnaire scores. The study was published on May 22, 2018, in the American Journal of Respiratory and Critical Care Medicine.

“Zephyr Valves offer clinically meaningful improvements in three important areas for patients - the ability to breathe better, be more active, and enjoy an improved quality of life,” said lead author Professor Gerard Criner, MD, of Temple University. “All primary and secondary endpoints were met, with Zephyr Valve treatment showing significant improvement for patients across multiple measures of breathing and quality of life. The Zephyr Valve also demonstrated an acceptable safety profile given the magnitude of benefit seen in this study.”

The Zephyr EBV is a one-way valve that blocks airflow to diseased regions of the lung, allowing healthy regions to expand and function more efficiently. The valves, which are either 4 or 5.5 millimeters in size, are implanted in a minimally invasive procedure using a bronchoscope equipped with a video camera. During the 60-minute procedure, 3-5 Zephyr valves are placed in airways leading to the diseased region of the lung. Once deployed, the self-expanding, one-way valve conforms to the bronchial wall and forms an airtight seal, blocking airflow to the diseased regions.

Related Links:
Temple University
University Medical Center Groningen
PulmonX

Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
New
Vertebral Body Replacement System
Hydrolift
New
Ultrasonic Cleaner
Cole-Parmer Ultrasonic Cleaner with Digital Timer

Print article

Channels

Critical Care

view channel
Image: Changes in immune cells can predict patient recovery following out-of-hospital cardiac arrest (Photo courtesy of Adobe Stock)

Activating T Cells Could Improve Neurological Outcomes After Cardiac Arrest

Despite advancements in cardiopulmonary resuscitation (CPR) and improved hospital access, survival rates after out-of-hospital cardiac arrest (OHCA) remain low, with only about 10% of patients surviving.... Read more

Patient Care

view channel
Image: The portable biosensor platform uses printed electrochemical sensors for the rapid, selective detection of Staphylococcus aureus (Photo courtesy of AIMPLAS)

Portable Biosensor Platform to Reduce Hospital-Acquired Infections

Approximately 4 million patients in the European Union acquire healthcare-associated infections (HAIs) or nosocomial infections each year, with around 37,000 deaths directly resulting from these infections,... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The acoustic pipette uses sound waves to test for biomarkers in blood (Photo courtesy of Patrick Campbell/CU Boulder)

Handheld, Sound-Based Diagnostic System Delivers Bedside Blood Test Results in An Hour

Patients who go to a doctor for a blood test often have to contend with a needle and syringe, followed by a long wait—sometimes hours or even days—for lab results. Scientists have been working hard to... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.