We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




New Stent Graft Design Improves Blood Flow

By HospiMedica International staff writers
Posted on 09 Sep 2015
A novel branching stent graft that can be deployed from the top on down could help patients suffering from thoracoabdominal aortic aneurysms (TAAAs).

Developed by researchers at Sanford Health (Sioux Falls, SD, USA) and South Dakota State University (SD State; Brookings, SD, USA) under an exclusive patent license agreement with Medtronic (Dublin, Ireland), the TAAA Debranching Stent Graft System is comprised of a thoracic bifurcation and visceral manifold graft, which work together to facilitate endovascular stenting of the visceral vessels—the renal, celiac, and superior mesenteric arteries—while maintaining blood flow to the visceral and infrarenal segments. More...


The complexity of the design required the use of computational fluid dynamics (CFD) simulations, conducted at SD State, in order to create a geometrically correct model of each graft relative to the same aorta coordinates and positioning in the body trunk, as well as the arteries that feed the organs and extend into the legs. To model blood flow near the artery walls (where atherosclerosis tends to begin), the researchers had to consider oscillating shear index, time-averaged wall shear stress, relative residence time, and wall shear stress temporal gradient.

To account for the transient pulsatile flow of blood, an extensive data table was entered into the software specifying the volumetric flow rate of blood through the system every 1/5,000 of a second, outputing a solution every 1/1,000 of a second to simulate a one-second cycle. The CFD simulations helped the researchers show that flow behavior next to the artery wall is more ordered, predictable, and moderate with the new stent design, splitting the blood flow upstream and letting it gradually come to the renal arteries. A study describing the system and the procedure were published in the November 2014 issue of the Journal of Vascular Surgery.

“Taking the complex and making it simple has long been our goal for the treatment of TAAAs. Working with Medtronic could eventually place our solution in the hands of vascular surgeons around the world to help patients facing a life-threatening condition,” said Sanford Health vascular surgeon Patrick Kelly, MD, who developed the concept. “We hope that this will have a major impact on the treatment of one of the most challenging disease processes to face our specialty.”

Degradation of structural proteins such as collagen and elastin, or a defect in their composition, leads to medial degeneration and weakening of the aortic wall. TAAA then results from a continuous dilation of the descending thoracic aorta, extending into the abdominal aorta. Subsequent dilatation results from hemodynamic forces on the arterial wall, as well as intrinsic changes in the composition of the arterial wall itself, which cause the diameter of the aorta to expand further and increase wall tension, thus creating a vicious cycle.

Medtronic plans to study the system in collaboration with physicians at several medical centers, including Dr. Kelly at Sanford Health, starting in the near future, with the purpose of subsequently commercializing the system after obtaining the required regulatory approvals.

Related Links:

Sanford Health
South Dakota State University
Medtronic



Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
New
Absorbable Monofilament Mesh
Phasix Mesh
New
Hospital Data Analytics App
Alarm History Analytics
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to HospiMedica.com and get access to news and events that shape the world of Hospital Medicine.
  • Free digital version edition of HospiMedica International sent by email on regular basis
  • Free print version of HospiMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of HospiMedica International in digital format
  • Free HospiMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Critical Care

view channel
Image: The skin-like sensor monitors internal and external body movement, and electrical signals (Photo courtesy of Huanyu “Larry” Cheng and Jennifer M. McCann)

Skin-Like Sensor Monitors Vital Signs and Tracks Healing After Surgery

Medical conditions such as bladder control issues and the need for monitoring vital signs after surgery require precise, long-term tracking to improve patient outcomes. These conditions can be challenging... Read more

Patient Care

view channel
Image: The revolutionary automatic IV-Line flushing device set for launch in the EU and US in 2026 (Photo courtesy of Droplet IV)

Revolutionary Automatic IV-Line Flushing Device to Enhance Infusion Care

More than 80% of in-hospital patients receive intravenous (IV) therapy. Every dose of IV medicine delivered in a small volume (<250 mL) infusion bag should be followed by subsequent flushing to ensure... Read more

Business

view channel
Image: A research collaboration aims to further advance findings in human genomics research in cardiovascular diseases (Photo courtesy of 123RF)

Bayer and Broad Institute Extend Research Collaboration to Develop New Cardiovascular Therapies

A research collaboration will focus on the joint discovery of novel therapeutic approaches based on findings in human genomics research related to cardiovascular diseases. Bayer (Berlin, Germany) and... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.