We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
Radcal

Download Mobile App




New Stent Graft Design Improves Blood Flow

By HospiMedica International staff writers
Posted on 09 Sep 2015
Print article
Image: The TAAA Debranching Stent Graft System (Photo courtesy of Sanford Health).
Image: The TAAA Debranching Stent Graft System (Photo courtesy of Sanford Health).
A novel branching stent graft that can be deployed from the top on down could help patients suffering from thoracoabdominal aortic aneurysms (TAAAs).

Developed by researchers at Sanford Health (Sioux Falls, SD, USA) and South Dakota State University (SD State; Brookings, SD, USA) under an exclusive patent license agreement with Medtronic (Dublin, Ireland), the TAAA Debranching Stent Graft System is comprised of a thoracic bifurcation and visceral manifold graft, which work together to facilitate endovascular stenting of the visceral vessels—the renal, celiac, and superior mesenteric arteries—while maintaining blood flow to the visceral and infrarenal segments.

The complexity of the design required the use of computational fluid dynamics (CFD) simulations, conducted at SD State, in order to create a geometrically correct model of each graft relative to the same aorta coordinates and positioning in the body trunk, as well as the arteries that feed the organs and extend into the legs. To model blood flow near the artery walls (where atherosclerosis tends to begin), the researchers had to consider oscillating shear index, time-averaged wall shear stress, relative residence time, and wall shear stress temporal gradient.

To account for the transient pulsatile flow of blood, an extensive data table was entered into the software specifying the volumetric flow rate of blood through the system every 1/5,000 of a second, outputing a solution every 1/1,000 of a second to simulate a one-second cycle. The CFD simulations helped the researchers show that flow behavior next to the artery wall is more ordered, predictable, and moderate with the new stent design, splitting the blood flow upstream and letting it gradually come to the renal arteries. A study describing the system and the procedure were published in the November 2014 issue of the Journal of Vascular Surgery.

“Taking the complex and making it simple has long been our goal for the treatment of TAAAs. Working with Medtronic could eventually place our solution in the hands of vascular surgeons around the world to help patients facing a life-threatening condition,” said Sanford Health vascular surgeon Patrick Kelly, MD, who developed the concept. “We hope that this will have a major impact on the treatment of one of the most challenging disease processes to face our specialty.”

Degradation of structural proteins such as collagen and elastin, or a defect in their composition, leads to medial degeneration and weakening of the aortic wall. TAAA then results from a continuous dilation of the descending thoracic aorta, extending into the abdominal aorta. Subsequent dilatation results from hemodynamic forces on the arterial wall, as well as intrinsic changes in the composition of the arterial wall itself, which cause the diameter of the aorta to expand further and increase wall tension, thus creating a vicious cycle.

Medtronic plans to study the system in collaboration with physicians at several medical centers, including Dr. Kelly at Sanford Health, starting in the near future, with the purpose of subsequently commercializing the system after obtaining the required regulatory approvals.

Related Links:

Sanford Health
South Dakota State University
Medtronic


Gold Member
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Pleuroscope
LTF-H290

Print article

Channels

Critical Care

view channel
Image: The AI model uses data from patients\' electronic health records to predict their chances of surviving CRRT (Photo courtesy of 123RF)

AI Model Accurately Predicts Continuous Renal Replacement Therapy Survival

Continuous renal replacement therapy (CRRT) is a type of dialysis used for severely ill patients who are unable to undergo regular hemodialysis. Although CRRT has been in use for many decades, there is... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: POCT offers cost-effective, accessible, and immediate diagnostic solutions (Photo courtesy of Flinders University)

POCT for Infectious Diseases Delivers Laboratory Equivalent Pathology Results

On-site pathology tests for infectious diseases in rural and remote locations can achieve the same level of reliability and accuracy as those conducted in hospital laboratories, a recent study suggests.... Read more

Business

view channel
Image: The finalists have been announced for the IHF Awards 2024 (Photo courtesy of IHF)

International Hospital Federation Awards 2024 Finalists Announced

The International Hospital Federation (IHF; Geneva, Switzerland) has announced the finalists of the IHF Awards 2024 after the judges completed scoring entries in all 7 Award categories. The IHF Awards... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.