We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
29 Aug 2020 - 02 Sep 2020
Virtual Venue

Primordial Goo Could Advance Medical Implant Technology

By HospiMedica International staff writers
Posted on 25 Nov 2015
Print article
Image: Primordial goo inspired polymer coating for implants (Photo courtesy of CSIRO).
Image: Primordial goo inspired polymer coating for implants (Photo courtesy of CSIRO).
An innovative prebiotic-chemistry inspired polymer coating could help biologically improve medical devices and implants.

Researchers at the Commonwealth Scientific and Industrial Research Organization (CSIRO; Melbourne, Australia) have developed a one-step polymerization-deposition process to manufacture aminomalononitrile (AMN), a hydrogen cyanide (HCN)-derived complex nitrogenous polymer. They found that the polymerization, when carried out in buffered aqueous solutions, can be used to coat a wide range of organic and inorganic substrate materials. The robust, non-cytotoxic coatings also provides for excellent cell attachment, suggesting potential biomedical applications.

According to the researchers, the non-toxic coating chemistry is adhesive and will coat almost any material, thus allowing for the immobilization of other compounds, including metals, both during coating formation or by performing secondary immobilization reactions. Silver compounds, for example, could be added to produce an antibacterial coating for catheters to avoid infections. Other compounds could be added to orthopedic implants to reduce friction, make them more durable and resistant to wear. The study was published on November 13, 2015, in NPG Asia Materials.

“The human body is a complex system, so there is a lot to consider when implanting artificial parts. Reducing the likelihood of infection and ensuring the body doesn't reject implants are ongoing medical challenges; that's why coatings on these implants are needed to help them to do their job,” said senior author Richard Evans, PhD, of the CSIRO manufacturing flagship. “We wanted to use these prehistoric molecules, which are believed to have been the source of all life evolving on Earth, to see if we could apply the chemistry in a practical way.”

Prebiotic chemistry (or chemical evolution) is the study of the chemistry required for producing the key molecules that eventually led to the origin of life. Experimental prebiotic chemistry started with a famous experiment by professor Stanley Miller used methane, hydrogen, ammonia, and an electrical spark to create complex organic compounds. Other HCN polymerization studies showed that prebiotic chemistry could have been a potential source of amino acids, nucleobases, and peptides on earth, and appear to be common throughout the solar system.

Related Links:

Commonwealth Scientific and Industrial Research Organization



Print article

Channels

Business

view channel
Illustration

Siemens to Acquire Varian Medical to Create Comprehensive Cancer Portfolio

Siemens Healthineers (Erlangen, Germany) has entered into an agreement to acquire Varian Medical Systems, Inc. (Palo Alto, CA, USA) that will lead to the creation of a global leader in healthcare with... Read more
Copyright © 2000-2020 Globetech Media. All rights reserved.