We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App




Innovative Surgical Glue Could Replace Sutures and Staples

By HospiMedica International staff writers
Posted on 08 Aug 2017
Print article
Image: Associate professor Julie Liu (L) and doctoral student Sydney Hollingshead prepare to test the new protein-based adhesive (Photo courtesy of Erin Easterling / Purdue).
Image: Associate professor Julie Liu (L) and doctoral student Sydney Hollingshead prepare to test the new protein-based adhesive (Photo courtesy of Erin Easterling / Purdue).
Adhesive proteins produced by mussels could be the basis for bioinspired, non-toxic surgical glue for moist environments, according to a new study.

Developed by researchers at Purdue University (Lafayette, IN, USA), ELY16 glue is made of an elastin-like polypeptide (ELP) modified by adding the enzyme tyrosinase. The modification forms mELY16, in which the tyrosine residues are converted to 3,4-dihydroxyphenylalanine (DOPA), an adhesive molecule. Both ELY16 and mELY16 are not toxic to cells and work well under dry conditions; but modification with DOPA increases adhesion strength in highly humid conditions. The modified version can be tuned to varying environmental conditions and different tissue types.

ELPs have the innate ability to coacervate, which causes them to separate into two liquid phases, one denser and more protein-rich than the other, mimicking the adhesion mechanism used by sandcastle worms and mussels. According to the researchers, ELP, which can be produced in high yields from E. coli, can coacervate in response to environmental factors such as temperature, pH, and salinity. In laboratory tests, mELY16 has significantly higher adhesion strength in humid and underwater environments than commercially available fibrin sealants. The study was published in the April 2017 issue of Biomaterials.

“Our goal was to mimic the type of adhesion that mussel adhesive proteins have, and much other work has focused on the DOPA molecule as being critical to that adhesion,” said senior associate professor of chemical engineering and biomedical engineering Julie Liu, PhD. “When the adhesive materials were exposed to large amounts of moisture, proteins containing DOPA had a much higher adhesion strength compared to unconverted proteins containing only tyrosine. So, DOPA conferred much stronger adhesion in wet environments.”

Elastin is a highly elastic protein found in connective tissues that allows them to resume their shape after stretching or contracting, for example in skin. Elastin serves an important function in arteries as a medium for pressure wave propagation to help blood flow, and is particularly abundant in large elastic blood vessels such as the aorta. Elastin is also very important in the lungs, helping them to contract, and in elastic ligaments and cartilage, where it helps store mechanical energy for load-bearing muscles.

Related Links:
Purdue University

Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
Silver Member
Compact 14-Day Uninterrupted Holter ECG
NR-314P
New
Neonatal Ventilator
Servo-n

Print article

Channels

Critical Care

view channel
Image: This study is significant as it addresses a treatment approach that has not been extensively studied before (Photo courtesy of 123RF)

Study Confirms Safety of DCB-Only Strategy for Treating De Novo Left Main Coronary Artery Disease

There has been a lack of extensive research on the use of drug-coated balloon (DCB)-only strategy for the treatment of de novo left main coronary artery disease, especially in high bleeding risk (HBR) patients.... Read more

Patient Care

view channel
Image: The newly-launched solution can transform operating room scheduling and boost utilization rates (Photo courtesy of Fujitsu)

Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization

An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.