We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App

Ultrasound Thalamotomy Relieves Parkinson's Disease Tremors

By HospiMedica International staff writers
Posted on 26 Feb 2020
Print article
Image: The InSightec ExAblate Neuro MRgFUS machine used in the study (Photo courtesy of University of L`Aquila)
Image: The InSightec ExAblate Neuro MRgFUS machine used in the study (Photo courtesy of University of L`Aquila)
Focused ultrasound thalamotomy provides a minimally invasive treatment option for patients with Parkinson's disease (PD) or essential tremor (ET), according to a new study.

Researchers at the University of L'Aquila (Italy) conducted a study involving 39 patients (average age 64.5 years), including 18 with ET and 21 with PD, who suffered from disabling tremors for an average of more than 10 years, and who had not responded to standard treatments. Patients were evaluated for tremor severity and quality of life before magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy, immediately after treatment, and over the course of the ensuing year. The procedures were performed with the InSightec (Dallas, TX, USA) ExAblate Neuro device, under guidance of a 3T MRI scanner.

The results revealed that 37 of 39 patients (95%) had substantial and immediate reduction of tremor, which were sustained during follow-up evaluations. Changes in fractional anisotropy and apparent diffusion coefficient (ADC) values in the ventral intermediate nucleus were statistically significant, but only changes in fractional anisotropy values correlated with clinical changes (based on the Fahn-Tolosa-Marin scale). In addition, quality of life was substantially improved in both the ET and PD groups. The study was presented at the Radiological Society of North America (RSNA) annual conference, held during November 2019 in Chicago (IL, USA).

“As a minimally invasive approach, focused ultrasound has advantages over deep brain stimulation, including a reduced risk of complications from bleeding and infections,” said lead author radiologist Federico Bruno, MD, of the department of biotechnological and applied clinical sciences. “Another advantage is the immediate effect this treatment provides, unlike deep brain stimulation which requires a break-in period for the electrostimulation. Additionally, treatment with MRgFUS requires shorter hospitalization, and is a fairly well-tolerated procedure even by more fragile patients.”

Focused ultrasound technology is based on nonlinear acoustic mathematical optimization methods to analyze and simulate the propagation of sound in material. The information is then used to enhance the shape of an acoustic lens in such a way that that ultrasound pressure is focused precisely on the location of the tissue to be ablated, while the surrounding tissue retains as little damage as possible.

Related Links:
University of L'Aquila

Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Gold Member
Solid State Kv/Dose Multi-Sensor
Silver Member
Wireless Mobile ECG Recorder
Pre-Op Planning Solution
Sectra 3D Trauma

Print article


Critical Care

view channel
Image: The new risk assessment tool determines patient-specific risks of developing unfavorable outcomes with heart failure (Photo courtesy of 123RF)

Powerful AI Risk Assessment Tool Predicts Outcomes in Heart Failure Patients

Heart failure is a serious condition where the heart cannot pump sufficient blood to meet the body's needs, leading to symptoms like fatigue, weakness, and swelling in the legs and feet, and it can ultimately... Read more

Patient Care

view channel
Image: The portable, handheld BeamClean technology inactivates pathogens on commonly touched surfaces in seconds (Photo courtesy of Freestyle Partners)

First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds

Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more

Health IT

view channel
Image: First ever institution-specific model provides significant performance advantage over current population-derived models (Photo courtesy of Mount Sinai)

Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients

Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more

Point of Care

view channel
Image: The Quantra Hemostasis System has received US FDA special 510(k) clearance for use with its Quantra QStat Cartridge (Photo courtesy of HemoSonics)

Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing

Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.