We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Comen Medical

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
24 Jan 2022 - 27 Jan 2022

Antibiotic Treatment for Appendicitis Does Not Obviate Surgery

By HospiMedica International staff writers
Posted on 07 Dec 2021
Print article
Image: Antibiotics for appendicitis may only delay surgery (Photo courtesy of Getty images)
Image: Antibiotics for appendicitis may only delay surgery (Photo courtesy of Getty images)
A new study suggests that although antibiotic therapy can prevent or delay an appendectomy, 50% of patients will eventually require surgery.

Researchers at the University of Washington (UW; Seattle, USA), Beth Israel Deaconess Medical Center (Boston, MA, USA), and other institutions conducted a study involving 1,552 patients with appendicitis at (414 of them with an appendicolith) who were randomized to receive antibiotics (776; 47% of whom were not hospitalized for the index treatment) or undergo appendectomy (776; 96% of whom underwent a laparoscopic procedure). The primary outcome was 30-day health status.

The results showed that although 20% of patients still needed an appendectomy within 30 days of beginning a 10-day antibiotic regimen, the percentage of patients in the antibiotics group who later underwent appendectomy was 40% after one year, 46% after two years, and was higher in patients with an appendicolith. The risks tended to plateau after two years, but the number of patients who were studied for that long was smaller. The study was published on October 25, 2021, in The New England Journal of Medicine.

“For the treatment of appendicitis, antibiotics were non-inferior to appendectomy, on the basis of results of a standard health-status measure,” concluded lead author David Flum, MD, of the UW School of Medicine, and colleagues. “In the antibiotics group, nearly three in ten participants had undergone appendectomy by 90 days. Participants with an appendicolith were at a higher risk for appendectomy and for complications than those without an appendicolith.”

An appendicolith is a calcified deposit of fecal matter within the appendix. They are present in a large number of children with acute appendicitis, and may be an incidental finding on an abdominal radiograph or CT. The presence of an appendicolith is an independent prognostic risk factor for treatment failure in non-operative treatment of uncomplicated acute appendicitis, and it has also been shown to be associated with appendiceal perforation.

Related Links:
University of Washington
Beth Israel Deaconess Medical Center

Print article



view channel

J&J Medical Devices Companies Partners with Microsoft to Further Enable its Digital Surgery Solutions

The Johnson & Johnson Medical Devices Companies (JJMDC; New Brunswick, NJ, USA) will collaborate with Microsoft (Redmond, Wash., USA) to further enable and expand JJMDC’s secure and compliant digital... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.