Laser-Based Imaging Technique Enables Much Faster Tissue Diagnosis during Tumor Surgery

The central nervous system can have around 120 different kinds of tumors, and the first step in treating them generally involves surgery along with acquiring histological samples. During this procedure, a small part of the tumor is excised and a histological frozen section is readied in the neuropathology department to better understand the tumor's features. Now, a newly developed laser-based imaging method allows neuropathologists to generate a report in just a matter of minutes.

Surgeons at Medical University Vienna (Vienna, Austria) have started employing this novel laser-based imaging method that considerably speeds up tissue diagnosis during tumor surgeries. Using Stimulated Raman Histology (SRH), a digital cross-section of the tissue can be instantly created right in the surgical suite, enabling a diagnosis within just a few minutes. In comparison, the standard method involving tissue transportation, manual preparation, and analysis usually takes around 30 minutes on an international average.

One of the advantages of this technique is that since the tissue is examined in its natural, untreated form, it remains fully available for any subsequent, more in-depth diagnostic tests. If SRH detects diagnostic tumor tissue, needle biopsies can also be concluded much more quickly. These procedures are not applicable just to brain tumors but can also be utilized for confirming diagnoses of other neurological conditions like blood vessel inflammatory diseases and demyelinating lesions. Initially developed in the United States, the SRH method was first adopted in Europe at the Department of Neurosurgery of MedUni Vienna and University Hospital Vienna, led by Georg Widhalm. A research study at MedUni Vienna showed a 99% correlation between digital histology and conventional frozen section.

"The new technology enables surgeons to make faster decisions regarding the optimal surgical strategy in the operating room, which significantly reduces the time in the operating room for patients. In addition, the safety of the procedure is also increased," said Georg Widhalm.

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